Table 2.
Change in Body Composition Parameters over Time
| Outcome Variable | 0–4 Weeks | 0–8 Weeks | 0–12 Weeks | P-Value Wk 0–4 |
P-Value Wk 0–8 |
P-Value Wk 0–12 |
Effect Size |
|---|---|---|---|---|---|---|---|
| Weight (lbs) | |||||||
| Aripiprazole | 3.57 (1.98, 5.16) | 7.43 (5.82, 9.04) | 9.87 (8.24, 11.50) | <0.001 | <0.001 | <0.001 | 1.86 |
| Olanzapine | 10.05 (7.58,12.52) | 14.85 (12.34, 17.36) | 18.97 (16.40, 21.54) | <0.001 | <0.001 | <0.001 | 2.16 |
| Quetiapine | 6.38 (3.95, 8.81) | 10.77 (8.28, 13.26) | 13.46 (10.89, 16.03) | <0.001 | <0.001 | <0.001 | 1.71 |
| Risperidone | 6.05 (4.93, 7.17) | 10.28 (9.12, 11.44) | 11.87 (10.69, 13.05) | <0.001 | <0.001 | <0.001 | 1.70 |
| Untreated | 2.23 (−0.77, 5.23) | 1.74 (−1.14, 4.62) | 0.43 (−2.31, 3.17) | 0.17 | 0.25 | 0.77 | 0.08 |
| Weight (Percent of Baseline) | |||||||
| Aripiprazole | 3.09 (1.78, 4.40) | 6.24 (4.91, 7.57) | 8.14 (6.97, 9.49) | <0.001 | <0.001 | <0.001 | 1.84 |
| Olanzapine | 8.34 (6.44, 10.24) | 12.17 (10.23, 14.11) | 15.20 (13.24, 17.16) | <0.001 | <0.001 | <0.001 | 2.27 |
| Quetiapine | 4.93 (3.13, 6.73) | 8.30 (6.46, 10.14) | 10.42 (8.54, 12.30) | <0.001 | <0.001 | <0.001 | 1.81 |
| Risperidone | 5.33 (4.43, 6.23) | 8.90 (7.96, 9.84) | 10.37 (9.41, 11.33) | <0.001 | <0.001 | <0.001 | 1.82 |
| Untreated | 1.67 (−0.51, 3.85) | 1.55 (−0.53, 3.63) | 0.65 (−1.33, 2.63) | 0.15 | 0.17 | 0.53 | 0.17 |
| Fat Mass (lbs) | |||||||
| Aripiprazole | 1.15 (−0.18, 2.48) | 3.09 (1.74, 4.44) | 5.39 (4.02, 6.76) | 0.10 | <0.001 | <0.001 | 1.20 |
| Olanzapine | 3.57 (1.79, 5.35) | 6.91 (5.11, 8.71) | 9.15 (7.31, 10.99) | 0.0002 | <0.001 | <0.001 | 1.45 |
| Quetiapine | 1.85 (0.20, 3.50) | 4.61 (2.85, 6.37) | 6.26 (4.46, 8.06) | 0.032 | <0.001 | <0.001 | 1.13 |
| Risperidone | 2.09 (1.31, 2.87) | 4.37 (3.53, 5.21) | 5.45 (4.59, 6.31) | <0.001 | <0.001 | <0.001 | 1.07 |
| Untreated | 0.78 (−1.10, 2.66) | 1.03 (−0.91, 2.97) | 0.77 (−0.95, 2.49) | 0.43 | 0.31 | 0.39 | 0.23 |
| BMI (kg/m2) | |||||||
| Aripiprazole | 0.62 (0.33, 0.91) | 1.28 (0.99, 1.57) | 1.67 (1.36, 1.98) | 0.001 | <0.001 | <0.001 | 1.63 |
| Olanzapine | 1.64 (1.25, 2.03) | 2.41 (2.00, 2.82) | 3.01 (2.60, 3.42) | <0.001 | <0.001 | <0.001 | 2.14 |
| Quetiapine | 1.03 (0.64, 1.42) | 1.74 (1.33, 2.15) | 2.12 (1.71, 2.53) | <0.001 | <0.001 | <0.001 | 1.68 |
| Risperidone | 1.01 (0.83, 1.19) | 1.71 (1.51, 1.91) | 1.92 (1.72, 2.12) | <0.001 | <0.001 | <0.001 | 1.65 |
| Untreated | 0.30 (−0.19, 0.79) | 0.21 (−0.26, 0.68) | −0.0032 (−0.45, 0.45) | 0.25 | 0.40 | 0.99 | 0.00 |
| BMI (Percent of Baseline) | |||||||
| Aripiprazole | 2.86 (1.53, 4.19) | 5.68 (4.35, 7.01) | 7.20 (5.83, 8.57) | 0.001 | <0.001 | <0.001 | 1.61 |
| Olanzapine | 7.88 (6.00, 9.76) | 11.45 (9.53, 13.17) | 14.04 (12.08, 16.00) | <0.001 | <0.001 | <0.001 | 2.09 |
| Quetiapine | 4.44 (2.68, 6.20) | 7.63 (5.81, 9.45) | 9.29 (7.43, 11.15) | <0.001 | <0.001 | <0.001 | 1.63 |
| Risperidone | 4.87 (3.99, 5.75) | 8.12 (7.20, 9.04) | 9.12 (8.18, 10.06) | <0.001 | <0.001 | <0.001 | 1.64 |
| Untreated | 1.25 (−0.89, 3.39) | 0.99 (−0.99, 2.97) | 0.05 (−1.89, 1.99) | 0.27 | 0.36 | 0.96 | 0.11 |
| BMI z-score | |||||||
| Aripiprazole | 0.16 (0.04, 0.28) | 0.31 (0.19, 0.43) | 0.37 (0.25, 0.49) | 0.007 | <0.001 | <0.001 | 0.96 |
| Olanzapine | 0.56 (0.38, 0.74) | 0.79 (0.61, 0.97) | 0.93 (0.75, 1.11) | <0.001 | <0.001 | <0.001 | 1.54 |
| Quetiapine | 0.18 (0.04, 0.32) | 0.38 (0.24, 0.52) | 0.44 (0.28, 0.60) | 0.02 | <0.001 | <0.001 | 0.92 |
| Risperidone | 0.35 (0.27, 0.43) | 0.53 (0.45, 0.61) | 0.60 (0.52, 0.68) | <0.001 | <0.001 | <0.001 | 1.29 |
| Untreated | 0.04 (−0.08, 0.16) | 0.02 (−0.10, 0.14) | −0.003 (−0.12, 0.11) | 0.52 | 0.80 | 0.96 | −0.01 |
| BMI Percentile | |||||||
| Aripiprazole | 4.38 (1.26, 7.50) | 6.97 (3.81, 10.13) | 8.44 (5.26, 11.62) | 0.008 | <0.001 | <0.001 | 0.81 |
| Olanzapine | 14.09 (9.35, 18.83) | 20.36 (15.54, 25.18) | 24.22 (19.32, 29.12) | <0.001 | <0.001 | <0.001 | 1.44 |
| Quetiapine | 4.86 (1.57, 8.15) | 9.33 (5.92, 12.74) | 10.86 (7.35, 14.37) | 0.006 | <0.001 | <0.001 | 1.01 |
| Risperidone | 9.38 (6.77, 11.99) | 14.69 (11.97, 17.41) | 16.42 (13.64, 19.20) | <0.001 | <0.001 | <0.001 | 1.00 |
| Untreated | 0.97 (−2.58, 4.52) | 0.66 (−2.75, 4.07) | 0.69 (−2.58, 3.96) | 0.60 | 0.71 | 0.69 | 0.11 |
| Waist (cm) | |||||||
| Aripiprazole | 2.20 (−0.33, 4.73) | 4.28 (1.75, 6.81) | 5.40 (2.87, 7.93) | 0.09 | 0.002 | 0.001 | 0.65 |
| Olanzapine | 4.09 (3.01, 5.17) | 6.79 (5.67, 7.91) | 8.55 (7.43, 9.67) | <0.001 | <0.001 | <0.001 | 2.44 |
| Quetiapine | 2.74 (1.62, 3.86) | 4.50 (3.34, 5.66) | 5.27 (4.07, 6.47) | <0.001 | <0.001 | <0.001 | 1.44 |
| Risperidone | 2.85 (2.28, 3.42) | 4.60 (4.01, 5.19) | 5.10 (4.49, 5.71) | <0.001 | <0.001 | <0.001 | 1.42 |
| Untreated | 0.84 (−0.87, 2.55) | 0.94 (−0.73, 2.61) | 0.70 (−0.87, 2.27) | 0.36 | 0.29 | 0.40 | 0.23 |
All change scores are reports as means ± 95% confidence intervals.
Bolded p values: <0.05