Table 3.

Adverse events prior to week 14

Adverse Event Outcome	Calcium acetate (N = 46)	Placebo (N = 64)	P-value
Patients with any adverse event	30 (65.2%)	42 (65.6%)	0.96
Any adverse event, rate (per subject per visit)	0.42	0.57	0.46
Patients with related adverse event	5 (10.9%)	9 (14.1%)	0.16
Related adverse event, rate (per subject per visit)	0.39	0.36	0.84
Adverse events related to medication by organ system class
Cardiac disorders	0	1 (1.6%)
Gastrointestinal disorders	3 (6.5%)	6 (9.4%)
General disorders	1 (2.2%)	0
Investigations	1 (2.2%)	0
Metabolism and nutrition disorders	2 (4.3%)	1 (1.6%)
Musculoskeletal and connective tissue disorders	0	1 (1.6%)
Skin and subcutaneous tissue disorders	0	1 (1.6%)
Vascular disorders	0	1 (1.6%)