Table 4.
Clinical characteristics of patients with emphysema score (ES) > 2 based on type of emphysema.
| Variable | ES > 2 Paraseptal (n = 7) |
ES > 2 Mixed (n = 8) |
ES > 2 Centrilobular (n = 13) |
P value |
|---|---|---|---|---|
| Age years; median [1st, 3rd] | 57 [51, 63] | 59 [57, 63] | 54 [49, 62] | NS* |
| Gender: | ||||
| Male, n | 7 | 8 | 2 | < 0.001† |
| Female, n | 0 | 0 | 11 | |
| Race: | ||||
| Caucasian, n | 3 | 6 | 7 | |
| African-American, n | 3 | 2 | 6 | NS† |
| Other, n | 1 | 0 | 0 | |
| Smoking packs/years; median [1st, 3rd] | 14 [0, 38] | 40 [38, 46] | 45 [25, 60] | < 0.05* |
| Right heart catheterization: | ||||
| Performed, n (%) | 5 (71) | 6 (75) | 6 (46) | NS† |
| Mean PAP mm Hg; median [1st, 3rd] | 32 [21, 34] | 31 [29, 33] | 25 [22, 31] | NS* |
| Surgical lung biopsy: | ||||
| Performed, n (%) | 6 (86) | 5 (63) | 9 (70) | NS† |
| UIP, n | 6 | 4 | 4 | < 0.05† |
| Fibrotic NSIP, n | 0 | 1 | 5 | |
| FVC % predicted; median, [1st, 3rd] | 57 [50, 60] | 59 [51, 63] | 71 [58, 84] | NS* |
| TLC % predicted; median, [1st, 3rd] | 58 [51, 64] | 60 [52, 69] | 72 [64, 86] | 0.05 |
| DLCO % predicted; median, [1st, 3rd] | 25 [21, 31] | 28 [23, 34] | 27 [18, 37] | NS* |
*Kruskal-Wallis one-way ANOVA; †Chi-square test.
Paraseptal, paraseptal emphysema; mixed, mixed centrilobular and paraseptal emphysema; centrilobular, centrilobular emphysema; mean PAP, mean pulmonary artery pressure; UIP, usual interstitial pneumonia; NSIP, non-specific interstitial pneumonia; FVC, forced vital capacity; TLC, total lung capacity; DLCO, diffusing capacity for carbon monoxide; NS, not significant (P > 0.05).