Table 1.
Study Characteristics
| Reference | Date of Diagnosis (range) | Exclusion Criteria | Patients With DM |
Age (years) | Follow-Up | Outcomes Reported | Adjustment Variables | |
|---|---|---|---|---|---|---|---|---|
| No./Total No. | % | |||||||
| Srokowski et al,19 2009 | 1992-2002 | < 66 years, not treated with definitive surgical therapy, previous cancer, no Medicare Part A and B, HMO member, noncarcinoma histology, stage IV disease | 14,414/70,781 | 20 | 66-70 (25%) 71-75 (27%) 76-80 (23%) 80+ (25%) | Range, 2-12 years | All-cause mortality, breast cancer mortality, stage at diagnosis, treatment, toxicity | Sex, diagnosis age, ethnicity, marital status, education level, poverty level, diagnosis year, SEER region, tumor grade, ER status, number positive lymph nodes, Charlson index, surgery type, use of chemotherapy or radiation |
| Lipscombe et al,6 2008 | 1995-2002 | Not 55-79 years, not living in Ontario, ineligible for universal health care, pre-existing breast cancer | 1,011/6,107 | 17 | DM: mean, 69.1 years NG: mean, 68.0 years | Mean, 5.0 years Range, 0-10.9 years | All-cause mortality | Age, income, comorbidity, screening mammogram |
| van de Poll-Franse et al,18 2007 | 1995-2002 | Not in the cancer registry | 754/9,725 | 8 | DM: mean, 70.7 years NG: mean, 58.9 years | Range, 3-10 years | All-cause mortality, stage at diagnosis, treatment | Age, stage, gender, treatment, cardiovascular disease |
| Du and Simon,21 2005 | 1994-1997 | Treatment received at an outside institution, race not black or white, < 1 year follow-up, stage IV disease | 73/588 | 12 | Mean, 59 years | Mean, 3.68 years | All-cause mortality, disease-free survival | Age, stage, nodal involvement, ER/PR status, race, comorbidity |
| Yancik et al,17 2001 | 1992 | < 55 years, unknown death information | NR/1,800 | 55-64 (35%) 65-74 (35%) > 75 (31%) | 30 months | All-cause mortality, stage at diagnosis, treatment | Age, stage, comorbidity | |
| Tammemagi et al,20 2005 | 1985-1990 | Not incident cancer, not Henry Ford Health System member, race not black or white | 127/906 | 14 | ≤ 40 years (8%) 40-50 years (18%) 50-60 years (19%) 60-70 years (24%) 70-80 years (22%) ≥ 80 years (9%) | Median, 10 years Range, 0.04-17.8 years | All-cause mortality | Unclear |
| Fleming et al,23 1999 | 1993 | < 67 years, not incident cancer, missing information on stage | 267/848 | 31.5 | > 67 years | 1 year | All-cause mortality, breast cancer mortality | None |
| Fleming et al,22 2005 | 1993-1995 | < 67 years, not covered by Medicare 2 years prior to cancer diagnosis or through 1998, prior breast cancer, > 1 primary cancers, HMO membership, diagnosis from autopsy, male | 3,182/17,468 | 18 | > 67 years | NA | Stage at diagnosis | Comorbidity, sociodemographic variables, screening, physician visits |
Abbreviations: DM, diabetes mellitus; ER/PR, estrogen receptor/progesterone receptor; HMO, health maintenance organization; NA, not applicable; NG, normoglycemic; NR, not reported; SEER, Surveillance, Epidemiology, and End Results.