Table 2.
Toxicity
| Adverse Event | No. of Adverse Events by Grade |
|||
|---|---|---|---|---|
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
| Leukopenia | 10 | 1 | 1 | 1 |
| Thrombocytopenia | 13 | 1 | 0 | 1 |
| Neutropenia | 7 | 1 | 1 | 1 |
| Anemia | 18 | 3 | 1 | 0 |
| Other hematologic | 0 | 0 | 1 | 0 |
| Allergy | 0 | 1 | 0 | 0 |
| Hearing | 1 | 0 | 0 | 0 |
| Cardiovascular | 16 | 6 | 1 | 1 |
| Coagulation | 2 | 0 | 1 | 0 |
| Constitutional | 38 | 11 | 2 | 1 |
| Dermatologic | 18 | 22 | 14 | 0 |
| Endocrine | 2 | 0 | 0 | 0 |
| GI | 35 | 18 | 3 | 0 |
| Genitourinary/renal | 1 | 0 | 1 | 0 |
| Hemorrhage | 3 | 1 | 0 | 0 |
| Infection | 0 | 3 | 0 | 0 |
| Lymphatic | 0 | 1 | 1 | 0 |
| Musculoskeletal | 3 | 4 | 0 | 0 |
| Metabolic | 28 | 5 | 8 | 2 |
| Neuropathy | 14 | 4 | 0 | 0 |
| Other neurologic | 10 | 0 | 1 | 0 |
| Ocular | 4 | 1 | 0 | 0 |
| Pain | 22 | 9 | 1 | 0 |
| Pulmonary | 7 | 0 | 1 | 1 |
NOTE. No. evaluated = 71.