Table 4.

Association of Biomarkers With Survival

Biomarker	Progression-Free Survival		Overall Survival
	HR	95% CI	HR	95%CI
pERK
Pretreatment	0.79	0.40-1.57	0.88	0.41-1.90
Post-treatment	0.45	0.22-0.93	1.41	0.64-3.07
ERK (pretreatment)	1.09	0.64-1.84	0.74	0.40-1.39
Raf (pretreatment)	0.85	0.50-1.45	1.02	0.55-1.90

Abbreviations: HR, hazard ratio; pERK, phosphorylated ERK.