Table 2.
Univariate Analyses of Overall and Event-Free Survival in Patients With Neuroblastoma
| Characteristic | No. | Overall Survival |
Event-Free Survival |
||||
|---|---|---|---|---|---|---|---|
| Hazard Ratio | 95% CI | P | Hazard Ratio | 95% CI | P | ||
| Race/ethnicity | |||||||
| White | 2,541 | 1.00 | 1.00 | ||||
| Hispanic | 418 | 1.01 | 0.79 to 1.31 | .92 | 0.90 | 0.72 to 1.12 | .33 |
| Black | 415 | 1.37 | 1.09 to 1.72 | .01 | 1.30 | 1.07 to 1.57 | .01 |
| Asian | 137 | 1.62 | 1.11 to 2.36 | .01 | 1.29 | 0.92 to 1.80 | .14 |
| Native American | 28 | 3.00 | 1.65 to 5.45 | .0003 | 2.37 | 1.37 to 4.10 | .002 |
| Age, months | |||||||
| < 18 | 1,758 | 1.00 | 1.00 | ||||
| ≥ 18 | 1,781 | 3.99 | 3.29 to 4.83 | < .001 | 3.02 | 2.61 to 3.51 | < .001 |
| Stage | |||||||
| 1, 2, 3, 4s | 1,895 | 1.00 | 1.00 | ||||
| 4 | 1,644 | 8.89 | 7.08 to 11.15 | < .001 | 5.08 | 4.34 to 5.95 | < .001 |
| Sex | |||||||
| Female | 1,618 | 1.00 | |||||
| Male | 1,921 | 1.15 | 0.98 to 1.34 | .09 | 1.11 | 0.97 to 1.26 | .13 |
| MYCN status | |||||||
| Not amplified | 2,645 | 1.00 | 1.00 | ||||
| Amplified | 658 | 5.22 | 4.41 to 6.17 | < .001 | 3.44 | 2.99 to 3.97 | < .001 |
| Ploidy | |||||||
| Hyperdiploid | 2,166 | 1.00 | 1.00 | ||||
| Diploid | 1,051 | 2.45 | 2.07 to 2.91 | < .001 | 2.02 | 1.75 to 2.32 | < .001 |
| Histology | |||||||
| Favorable | 1,661 | 1.00 | 1.00 | ||||
| Unfavorable | 1,466 | 11.60 | 8.65 to 15.56 | < .001 | 4.93 | 4.12 to 5.90 | < .001 |
| Risk group | |||||||
| Low | 1,185 | 1.00 | 1.00 | ||||
| Intermediate | 718 | 2.22 | 1.29 to 3.83 | .004 | 1.31 | 0.97 to 1.78 | .08 |
| High | 1,636 | 23.28 | 15.47 to 35.04 | < .001 | 6.99 | 5.67 to 8.61 | < .001 |
NOTE. Bold font denotes groups at statistically significantly higher risk of death and/or event.