Table A1.
Children's Oncology Group Neuroblastoma Risk Classification System
| Stage | Age (days) | MYCN | Ploidy | Histology | Other | Risk Group |
|---|---|---|---|---|---|---|
| 1 | Low | |||||
| 2A/2B | NA | > 50% resected | Low | |||
| NA | < 50% resected | Intermediate | ||||
| NA | Bx only | Intermediate | ||||
| Amp | High | |||||
| 3 | < 547 | NA | Intermediate | |||
| ≥ 547 | NA | FH | Intermediate | |||
| Amp | High | |||||
| ≥ 547 | NA | UH | High | |||
| 4 | < 365 | Amp | High | |||
| < 365 | NA | Intermediate | ||||
| 365-< 547 | Amp | High | ||||
| 365-< 547 | DI = 1 | High | ||||
| 365-< 547 | UH | High | ||||
| 365-< 547 | NA | DI > 1 | FH | Intermediate | ||
| ≥ 547 | High | |||||
| 4S | < 365 | NA | DI > 1 | FH | Asymptomatic | Low |
| < 365 | NA | DI = 1 | Intermediate | |||
| < 365 | Missing | Missing | Missing | Intermediate | ||
| < 365 | NA | Symptomatic | Intermediate | |||
| < 365 | NA | UH | Intermediate | |||
| < 365 | Amp | High |
Abbreviations: NA, not amplified; Bx, biopsy; Amp, amplified; FH, favorable histology; UH, unfavorable histology; DI, DNA index.