Table 1. Reduction of bacterial load and more rapid clearance in a murine colonization model by immunization with recombinant B. abortus Mdh.
Time, Post-infection (days) | Adjuvant Only | Mdh | p value | Log reduction |
0 | - | - | - | - |
7 | 2.51×106(+/− 3.34×105) | 8.05×105(+/− 5.62×105) | <0.05 | 0.55 |
14 | 9.94×107(+/− 2.17×107) | 2.43×105(+/− 1.12×105) | <0.001 | 2.75 |
21 | 2.64×106(+/− 8.57×105) | 3.73×104(+/− 2.08×104) | <0.001 | 2.09 |
28 | 1.38×105(+/− 8.37×104) | 1.29×104(+/− 1.00×104) | <0.05 | 1.09 |