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. 2011 Mar 11;6(3):e17537. doi: 10.1371/journal.pone.0017537

Figure 3. Sequence logos showing the most conserved bases for miRNAs in one family.

Figure 3

The miRNA sequence logos for 15 lcal-miRNA families with multiple sequences (≥2) are presented. Each logo consists of stacks of symbols, one stack for each position in the sequence. The overall height of the stack indicates the sequence conservation at that position, while the height of symbols within the stack indicates the relative frequency of each nucleotide at that position. Some miRNAs from one family differ only by a few base pairs on either side and/or in the middle (e.g. let-7, mir-9, mir-21, mir-124 and mir-126); the mir-199 family is highly divergent, since the two miRNAs in that might be from the 5′ arm and from the 3′ arm of a pre-miRNA, respectively.