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. 2011 Mar 11;6(3):e17669. doi: 10.1371/journal.pone.0017669

Figure 2. Biochemical profiles in Tg2576 and wildtype littermate mice and in cell culture.

Figure 2

(A) Tg2576 mice have significant deficits in a number of proteins, as compared to age-matched wildtype controls, and PBT2-treatment significantly increases the expression of a number of these proteins to the levels seen in the control mice. Values have been normalized to the mean of Tg Sham group = 100. (B) The effect of PBT2 on NMDAR1 protein levels in SH-SY5Y cells is abolished in the presence of the high affinity chelator, diamsar (n = 6/treatment). *p<0.05, **p<0.01, #p = 0.06.