Table 3. Results of the multiplex immunoassays in tissue homogenates (A) and/or cerebrospinal fluid (B).
| A) | Hippocampus [pg/mg total protein] (72 h pi) | Cortex [pg/mg total protein] (72 h pi) | ||||||||
| Protein | CS (n = 4) | CD (n = 4) | IS (n = 5) | ID (n = 7) | Ratio (ID/IS) | CS (n = 4) | CD (n = 4) | IS (n = 5) | ID (n = 7) | Ratio (ID/IS) |
| MIP-1a/CCL3 | 1.70 | 0.48 | 6.69 | 1.76 | 0.26 * | 0.27 | 0.70 | 3.78 | 0.91 | 0.24 * |
| MCP-1/CCL2 | 5.43 | 8.84 | 8.84 | 5.01 | 0.57 * | 3.27 | 4.77 | 7.44 | 3.51 | 0.47 * |
| RANTES/CCL5 | 7.40 | 8.05 | 39.59 | 15.63 | 0.39 * | 6.13 | 7.10 | 25.32 | 10.88 | 0.43 * |
| IP-10/CXCL10 | - | - | - | - | - | - | - | - | - | - |
| TNF-a | 5.91 | 7.12 | 5.93 | 4.49 | 0.76 | 3.38 | 3.97 | 2.63 | 2.24 | 0.85 |
| IFN-g | - | - | 3.57 | 5.03 | 1.41 | - | - | 1.84 | 2.28 | 1.24 |
| IL-1b | 16.13 | 13.60 | 19.28 | 12.92 | 0.65 | 6.92 | 6.94 | 17.37 | 8.59 | 0.49 |
| IL-2 | 37.51 | 39.56 | 16.80 | 14.77 | 0.88 | 17.57 | 22.03 | 15.15 | 8.69 | 0.57 |
| IL-6 | 24.98 | 18.72 | 16.35 | 16.97 | 1.04 | 14.77 | 12.22 | 8.22 | 10.54 | 1.28 |
| IL-10 | 7.16 | 6.91 | 4.60 | 3.26 | 0.71 | 4.18 | 3.82 | 2.31 | 2.52 | 1.09 |
| BDNF (n = 6 for “C”) | 52.89 | 45.53 | 27.05 | 59.26 | 2.19 | 5.60 | 4.52 | 4.88 | 9.12 | 1.87 |
Results are given as median. “-” indicates values that were below detection limit. * p<0.05 was considered as significantly different. pi = post infection, C = control animals, S = saline treatment, D = dexamethasone treatment, I = infected animals, CSF = cerebrospinal fluid.