Table 3.
Biological index calculations for single tumor infusion site (a), increased specific activity (b), and multiple tumor infusion sites (c).
| Tumor volume (cm3) | Injected activity (MBq) | EUD (Gy) | TCP (%) | Average dose (Gy) | |||||
|---|---|---|---|---|---|---|---|---|---|
| 186Re | 188Re | 186Re | 188Re | 186Re | 188Re | 186Re | 188Re | ||
| (a) | |||||||||
| Rat 1 | 1.57 | 76.96 | 76.96 | 4.64 | 10.17 | 0.00 | 0.00 | 767.81 | 496.12 |
| Rat 2 | 1.84 | 92.13 | 92.13 | 4.63 | 9.18 | 0.00 | 0.00 | 588.97 | 399.87 |
| Rat 3 | 1.28 | 64.75 | 64.75 | 6.55 | 16.58 | 0.00 | 27.85 | 542.43 | 287.41 |
| Rat 4 | 0.78 | 37.37 | 37.37 | 6.04 | 27.81 | 0.00 | 98.99 | 360.21 | 274.97 |
| Average ±SD | 1.36±0.46 | 67.80±23.17 | 67.80±23.17 | 5.47±0.98 | 15.94±8.57 | 0.00±0.00 | 31.71±46.74 | 564.86±167.49 | 364.59±104.14 |
| (b) | |||||||||
| Rat 1 | 1.57 | 10 020.3 | 616.8 | 29.95 | 30.53 | 99.09 | 99.28 | 99 815.38 | 3968.92 |
| Rat 2 | 1.84 | 15 639.5 | 1195.8 | 30.26 | 30.18 | 99.07 | 99.04 | 100 124.65 | 5198.29 |
| Rat 3 | 1.28 | 5 301.0 | 193.9 | 29.40 | 30.03 | 99.10 | 99.29 | 44 479.13 | 862.24 |
| Rat 4 | 0.78 | 1 268.0 | 37.4 | 28.19 | 27.81 | 99.12 | 98.99 | 12 247.07 | 274.971 |
| Average ±SD | 1.36±0.46 | 8 057.2±6 192.4 | 511.0±518.0 | 29.45±0.91 | 29.64±1.24 | 99.10±0.02 | 99.15±0.16 | 64 166.56±43 386.06 | 2576.11±2383.86 |
| (c) | |||||||||
| Rat 1 | 1.57 | 76.96 | 76.96 | 50.20 | 74.02 | 100.00 | 100.00 | 752.84 | 480.73 |
| Rat 2 | 1.84 | 92.13 | 92.13 | 30.95 | 35.10 | 99.28 | 99.86 | 562.45 | 378.50 |
| Rat 3 | 1.28 | 64.75 | 64.75 | 92.19 | 112.00 | 100.00 | 100.00 | 494.69 | 256.41 |
| Rat 4 | 0.78 | 37.37 | 37.37 | 46.67 | 93.49 | 100.00 | 100.00 | 364.19 | 270.99 |
| Average ±SD | 1.36±0.46 | 67.80±23.17 | 67.80±23.17 | 55.00±26.17 | 78.65±32.92 | 99.8±0.36 | 99.97±0.07 | 543.54±161.98 | 346.66±104.66 |