Table 4. GENEVA Phenotype Working Groups.

Working Group	Key variable(s) defined	No. of contributing studies so far	Approx. N	Comment
Alcohol use	Drinks per week, reported maximum, as a continuous measure	7	18,000	First studies used for replication; Meta-analysis to be considered when data on later studies are available
Anthropometric measures	Height (m), continuous	7	42,000
	Weight (kg) at study entry	6	36,000
	Body Mass Index (BMI)	3	36,000
	Weight (kg) at late adolescence or early adulthood	3	25,000	To be analyzed as part of a broader consortium with other, non-GENEVA studies
	Adult weight gain	3	25,000	To be analyzed as part of a broader consortium with other, non-GENEVA studies
	Waist circumference (cm) at study entry (also waist adjusted for BMI and height)	3	24,000
	Hip circumference (cm) at study entry	2	23,000
Caffeine use	Caffeine intake per day (mg/day)	3	25,000	Meta-analysis, including findings from subjects not part of GENEVA
Diabetes	On hold
Hypertension	Only two studies have actual blood pressure measures; discussing collaboration with another consortium
Oral health	Various dental caries and periodontal disease variables (under development)	3	TBD
Physical activity and exercise	Metabolic equivalent moderate/vigorous leisure activity min/day (continuous); Engagement in moderate/vigorous leisure activity (dichotomized)	6	TBD	Planned meta-analysis, In-silico/de novo replication
Protective effects	Under development	10	TBD
Psychiatric history	Too much variance in the instruments to develop a meaningful harmonized variable across studies
Reproductive history	Age at menarche	8	18,000	Four studies collaborated with another consortium for analysis
	Age at menopause		8,500
	Spontaneous loss	TBD	TBD
Sleep	New working group, under development
Tobacco use	G*E interactions	4	15,000	Under development

TBD = To be determined