TABLE 1.
Clinical and pathological characteristics of men in the SEARCH database who started ADT after RP stratified by whether they gained weight or lost weight/had no change in the weight in the first year of ADT
| Variable | Total | Weight gainers | Weight losers | P* |
|---|---|---|---|---|
| No. of patients (%) | 132 | 92 (70) | 40 (30) | |
| Mean (sd): | ||||
| weight change, kg | 2.2 (4.1) | 4.2 (2.9) | −2.4 (2.4) | |
| age at ADT, years | 66 (8) | 66 (8) | 66 (8) | 0.81† |
| Median (IQR): | ||||
| year of ADT | 2003 (‘01–‘05) | 2003 (‘01–‘05) | 2003 (‘01–‘05) | 0.75‡ |
| N (%): | ||||
| Race: | 0.25 | |||
| White | 66 (50) | 47 (51) | 19 (48) | |
| Black | 56 (42) | 36 (39) | 20 (50) | |
| Other | 10 (8) | 9 (10) | 1 (2) | |
| Centre: | 0.61 | |||
| 1 | 38 (29) | 27 (29) | 11 (27) | |
| 2 | 26 (20) | 20 (22) | 6 (15) | |
| 3 | 16 (12) | 12 (13) | 4 (10) | |
| 4 | 52 (39) | 33 (36) | 19 (48) | |
| Mean (sd): | ||||
| pre-ADT BMI, kg/m2 | 29.0 (4.8) | 28.4 (4.4) | 30.0 (5.5) | 0.10† |
| Median (IQR): | ||||
| pre-ADT PSA level, ng/mL | 1.0 (0.2–4.8) | 1.0 (0.2–5.6) | 1.2 (0.4–2.8) | 0.86‡ |
| N (%): | ||||
| Pathological Gleason: | 0.74 | |||
| ≤6 | 22 (17) | 15 (16) | 7 (18) | |
| 3 + 4 | 46 (35) | 34 (37) | 12 (30) | |
| ≥4 + 3 | 64 (48) | 43 (47) | 21 (53) | |
| Extracapsular extension: | 0.33 | |||
| positive | 57 (44) | 42 (47) | 15 (38) | |
| negative | 73 (56) | 48 (53) | 25 (63) | |
| Surgical margins: | 0.56 | |||
| positive | 91 (31) | 62 (67) | 29 (73) | |
| negative | 41 (69) | 30 (33) | 11 (27) | |
| Seminal vesicle invasion: | 0.99 | |||
| positive | 46 (35) | 32 (35) | 14 (35) | |
| negative | 85 (65) | 59 (65) | 26 (65) | |
| Lymph node status: | 0.68 | |||
| 0 | 100 (76) | 71 (77) | 29 (73) | |
| 1 | 8 (6) | 6 (7) | 2 (5) | |
| 2 | 24 (18) | 15 (16) | 9 (22) |
*
P-value from chi-squared except where noted;
†
P-value from t-test;
‡
rank sum.