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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Psychopharmacology (Berl). 2010 Nov 16;214(3):707–718. doi: 10.1007/s00213-010-2076-4

Fig. 8.

Fig. 8

Loss of BBB integrity leads to neurodegeneration. a–c Primary human neurons cultured on glass cover slips (40,000 cells/well) were treated with 50 mM EtOH ± ALC for 48 h and were analyzed for the integrity of neurofilaments (NF; green)in a control, b EtOH, and c EtOH + ALC (ALC=200 μM). d–f Effect of chronic EtOH administration on dopaminergic neurons (the expression of dopaminergic neuronal marker, tyrosine hydroxylase (TH), green) and g–i on cholinergic neurons (the expression of cholinergic neuronal marker, choline acetyltransferase (ChAT), green) are shown in brain cortical tissue sections. Scale bar indicated 10 μmin a–c and 20 μmin d–i