Table 2.

Type I error rates

Ascertainment	Control	Method	Sibship	Nuclear	Moderate Pedigree	Extended Pedigree
Random	Familial	VC	0.052	0.048	0.049	0.049
		Naïve	0.053	0.049	0.048	0.050
		Weight	0.035	0.024	0.031	0.028
		MQLS	0.052	0.050	0.048	0.052
	Independent	VC	0.051	0.045	0.045	0.049
		Naïve	0.066	0.066	0.059	0.078
		Weight	0.053	0.051	0.048	0.060
		MQLS	0.053	0.040	0.046	0.045
Selective	Familial	VC	0.058	0.052	0.051	0.055
		Naïve	0.016	0.024	0.039	0.054
		Weight	0.000	0.003	0.004	0.024
		MQLS	0.058	0.050	0.046	0.048
	Independent	VC	0.050	0.055	0.057	0.048
		Naïve	0.084	0.100	0.103	0.092
		Weight	0.057	0.059	0.062	0.064
		MQLS	0.051	0.048	0.047	0.050

Note: For 5000 simulations and considering a multiple testing correction to correct for the 16 scenarios, the 95% confidence interval for a type 1 error of 0.05 is (0.041 to 0.060). Bold values represent significantly inflated from a type 1 error of 0.05 (anti-conservative) and underlined values significantly reduced type 1 error of 0.05 (conservative). VC, variance correction.