Table 3.
Genotype distribution and association with chronic hepatitis B, Han population from Northern China
| SNP | Genotype | Carriers (%) |
Controls (%) |
Clearances (%) |
Carriers vs Controls | Carriers vs Clearances | ||
|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | p value | OR (95%CI) | p value | |||||
| rs2395309 | GG | 226 (45.6) | 261 (32.4) | 175 (31.0) | 1.0 | 1.0 | ||
| AG | 209 (42.1) | 371 (46.1) | 262 (46.5) | 0.71 (0.55-0.92) | 0.0097 | 0.65 (0.49-0.87) | 0.0038 | |
| AA | 61 (12.3) | 173 (21.5) | 127 (22.5) | 0.47 (0.33-0.67) | 4E-05 | 0.42 (0.29-0.62) | 1.10E-05 | |
| rs3077 | GG | 247 (48.0) | 259 (32.0) | 180 (32.0) | 1.0 | 1.0 | ||
| AG | 211 (41.1) | 382 (47.3) | 262 (46.6) | 0.63 (0.48-0.81) | 0.0004 | 0.63 (0.47-0.83) | 0.0012 | |
| AA | 56 (10.9) | 167 (20.7) | 120 (21.4) | 0.39 (0.27-0.57) | 6.7E-07 | 0.37 (0.25-0.55) | 7.89E-07 | |
| rs2301220 | TT | 232 (45.6) | 241 (30.3) | 166 (29.8) | 1.0 | 1.0 | ||
| CT | 215 (42.2) | 384(48.2) | 270 (48.5) | 0.64 (0.49-0.83) | 0.0008 | 0.61 (0.46-0.81) | 0.0007 | |
| CC | 62 (12.2) | 171 (21.5) | 121 (21.7) | 0.42 (0.30-0.61) | 3E-06 | 0.40 (0.27-0.59) | 4.83E-06 | |
| rs9277341 | CC | 388 (75.9) | 472 (58.6) | 334 (59.3) | 1.0 | 1.0 | ||
| CT | 110 (21.5) | 284 (35.3) | 191 (33.9) | 0.50 (0.38-0.65) | 4.6E-07 | 0.51 (0.38-0.69) | 8.28E-06 | |
| TT | 13 (2.6) | 49 (6.1) | 38 (6.8) | 0.33 (0.18-0.64) | 0.0009 | 0.30 (0.16-0.60) | 0.0005 | |
| rs3135021 | GG | 260 (50.6) | 351 (43.2) | 239 (42.2) | 1.0 | 1.0 | ||
| AG | 206 (40.1) | 363 (44.6) | 249 (44.0) | 0.77 (0.60-0.98) | 0.036 | 0.77 (0.59-1.02) | 0.067 | |
| AA | 48 (9.3) | 99 (12.2) | 78 (13.8) | 0.66 (0.44-0.99) | 0.045 | 0.55 (0.36-0.85) | 0.007 | |
| rs9277535 | AA | 98 (19.7) | 266 (33.5) | 193 (34.9) | 1.0 | 1.0 | ||
| AG | 217 (43.6) | 364 (45.8) | 256 (46.3) | 1.56 (1.16-2.11) | 0.0035 | 1.69 (1.22-2.33) | 0.0014 | |
| GG | 183 (36.7) | 164 (20.7) | 104 (18.8) | 2.75 (1.98-3.82) | 1.9E-09 | 3.25 (2.26-4.68) | 2.06E-10 | |
| rs10484569 | GG | 175 (34.1) | 402 (49.8) | 281 (49.8) | 1.0 | 1.0 | ||
| AG | 237 (46.1) | 318 (39.4) | 229 (40.6) | 1.67 (1.29-2.17) | 9.3E-05 | 1.63 (1.23-2.15) | 0.0007 | |
| AA | 102 (19.8) | 87 (10.8) | 54 (9.6) | 2.46 (1.73-3.52) | 7E-07 | 2.80 (1.87-4.20) | 6.12E-07 | |
| rs3128917 | TT | 106 (20.4) | 320 (39.5) | 233 (41.2) | 1.0 | 1.0 | ||
| GT | 263 (50.7) | 358 (44.1) | 245 (43.3) | 2.18 (1.64-2.91) | 8.5E-08 | 2.40 (1.76-3.26) | 2.57E-08 | |
| GG | 150 (28.9) | 133 (16.4) | 88 (15.5) | 3.17 (2.26-4.45) | 2.4E-11 | 3.53 (2.43-5.12) | 3.24E-11 | |
| rs2281388 | GG | 175 (34.9) | 411 (51.3) | 288 (51.8) | 1.0 | 1.0 | ||
| AG | 238 (47.4) | 316 (39.5) | 222 (39.9) | 1.77 (1.37-2.29) | 1.5E-05 | 1.79 (1.35-2.37) | 4.93E-05 | |
| AA | 89 (17.7) | 74 (9.2) | 46 (8.3) | 2.67 (1.83-3.89) | 3.1E-07 | 3.09 (2.01-4.74) | 2.50E-07 | |
| rs3117222 | CC | 104 (20.3) | 319 (40.3) | 231 (41.8) | 1.0 | 1.0 | ||
| CT | 260 (50.9) | 344 (43.5) | 236 (42.8) | 2.36 (1.77-3.16) | 6E-09 | 2.56 (1.87-3.50) | 3.56E-09 | |
| TT | 147 (28.8) | 128 (16.2) | 85 (15.4) | 3.34 (2.37-4.71) | 5.7E-12 | 3.68 (2.52-5.36) | 1.30E-11 | |
| rs9380343 | CC | 165 (32.9) | 397 (49.3) | 280 (49.8) | 1.0 | 1.0 | ||
| CT | 239 (47.7) | 325 (40.3) | 231 (41.1) | 1.81 (1.39-2.35) | 8.3E-06 | 1.84 (1.39-2.44) | 2.36E-05 | |
| TT | 97 (19.4) | 84 (10.4) | 51 (9.1) | 2.65 (1.84-3.82) | 1.5E-07 | 3.12 (2.06-4.73) | 7.84E-08 | |