Table 3.
Average PCVD between the methods in directional (top) and absolute (bottom) terms (see text for details)
| Region |
Alcoholics |
Controls |
Overall F |
Group effect |
Sex effect |
Group × Sex interaction |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Females n = 19 Mean ± SD | Males n = 13 | Females n = 17 | Males n = 20 | F-value | P-value | F-value | P-value | F-value | P-value | F-value | P-value | |
| Percentage common volume difference | ||||||||||||
| L cerebral cortex | 31.6 ± 12.7 | 20.4 ± 13.8 | 26.2 ± 13.9 | 24.2 ± 12.9 | 2.0 | 0.12 | 0.1 | 4.2 | 0.04 | 2.0 | ||
| R cerebral cortex | 30.6 ± 13.4 | 19.3 ± 15.9 | 25.8 ± 14.1 | 24.8 ± 12.2 | 1.8 | 0.1 | 3.4 | 0.07 | 2.4 | 0.13 | ||
| L cerebral white matter | 7.1 ± 8.3 | 12.3 ± 11.9 | 10.8 ± 11.2 | 2.7 ± 7.4 | 3.4 | 0.02 | 1.6 | 0.4 | 8.1 | 0.01 | ||
| R cerebral white matter | 6.1 ± 8.0 | 10.6 ± 10.7 | 9.7 ± 8.9 | 1.8 ± 6.8 | 3.9 | 0.01 | 1.5 | 0.7 | 9.0 | 0.004 | ||
| L Lat Vent | 5.3 ± 6.1 | 0.2 ± 15.4 | 2.4 ± 6.5 | 0.2 ± 7.1 | 1.3 | 0.4 | 2.9 | 0.10 | 0.5 | |||
| R Lat Vent | 4.1 ± 9.2 | −5.0 ± 11.0 | 3.0 ± 8.9 | −0.8 ± 9.3 | 2.9 | 0.04 | 0.5 | 7.8 | 0.01 | 1.3 | ||
| L thalamus | 13.9 ± 5.6 | 12.0 ± 8.8 | 13.9 ± 9.2 | 6.3 ± 9.0 | 3.7 | 0.02 | 2.0 | 5.6 | 0.02 | 2.1 | ||
| R thalamus | 13.1 ± 5.9 | 13.0 ± 9.4 | 15.2 ± 7.1 | 8.3 ± 8.7 | 2.7 | 0.06 | 0.5 | 3.4 | 0.07 | 3.2 | 0.08 | |
| L hippocampus | −0.9 ± 8.5 | 12.7 ± 20.5 | −0.5 ± 9.4 | −6.8 ± 10.4 | 6.7 | 0.0005 | 10.2 | 0.002 | 1.5 | 11.0 | 0.001 | |
| R hippocampus | −0.1 ± 7.6 | 9.6 ± 14.3 | −3.3 ± 10.3 | −7.5 ± 9.8 | 7.4 | 0.0002 | 16.0 | 0.0002 | 1.2 | 7.5 | 0.01 | |
| L amygdala | −0.7 ± 14.8 | 6.8 ± 14.6 | −4.9 ± 17.5 | −5.0 ± 18.8 | 1.6 | 3.8 | 0.05 | 0.8 | 0.9 | |||
| R amygdala | −4.9 ± 14.5 | −6.5 ± 12.8 | −6.0 ± 18.7 | −9.2 ± 18.5 | 0.2 | 0.2 | 0.3 | 0.1 | ||||
| L caudate | −0.9 ± 9.1 | −4.3 − 8.4 | −2.2 ± 9.9 | 0.4 ± 8.8 | 0.8 | 0.6 | 0.1 | 1.8 | ||||
| R caudate | −0.9 ± 8.0 | −0.1 ± 13.5 | 2.8 ± 6.5 | 5.9 ± 8.8 | 2.2 | 0.10 | 4.8 | 0.03 | 0.8 | 0.3 | ||
| L putamen | −3.9 ± 9.5 | 6.3 ± 24.3 | −6.8 ± 10.6 | −5.3 ± 6.4 | 2.8 | 0.04 | 5.1 | 0.03 | 3.3 | 0.07 | 1.8 | |
| R putamen | 1.5 ± 10.0 | 6.3 ± 18.1 | 0.7 ± 12.1 | 0.2 ± 7.7 | 0.8 | 1.4 | 0.6 | 0.8 | ||||
| L pallidum | −20.0 ± 10.6 | −16.9 ± 18.9 | −13.0 ± 15.1 | −9.9 ± 14.4 | 1.7 | 3.8 | 0.06 | 0.8 | 0.1 | |||
| R pallidum | −17.8 ± 16.4 | 0.7 ± 6.6 | −5.7 ± 14.5 | −15.4 ± 18.4 | 5.0 | 0.003 | 0.3 | 1.4 | 14.4 | 0.0003 | ||
| L accumbens area | 19.6 ± 21.5 | 40.8 ± 55.2 | 6.1 ± 32.9 | 11.9 ± 21.8 | 3.0 | 0.04 | 6.8 | 0.01 | 2.8 | 0.10 | 0.9 | |
| R accumbens area | 12.8 ± 29.6 | 64.4 ± 50.3 | 7.3 ± 42.0 | −4.2 ± 27.7 | 9.8 | <0.0001 | 16.8 | 0.0001 | 4.9 | 0.03 | 12.2 | 0.001 |
| Absolute percentage common volume difference | ||||||||||||
| L cerebral cortex | 31.6 ± 12.7 | 21.1 ± 12.6 | 27.8 ± 9.9 | 25.1 ± 10.9 | 2.3 | 0.08 | 0.1 | 5.5 | 0.02 | 1.9 | ||
| R cerebral cortex | 30.6 ± 13.4 | 21.0 ± 13.3 | 27.3 ± 10.6 | 25.5 ± 10.4 | 1.8 | 0.1 | 3.8 | 0.05 | 1.8 | |||
| L cerebral white matter | 8.4 ± 7.0 | 13.9 ± 9.9 | 12.1 ± 9.6 | 5.8 ± 5.2 | 3.6 | 0.02 | 1.3 | 0.1 | 9.6 | 0.003 | ||
| R cerebral white matter | 8.1 ± 5.7 | 11.3 ± 9.8 | 10.6 ± 7.8 | 5.4 ± 4.4 | 2.6 | 0.06 | 1.0 | 0.4 | 6.2 | 0.02 | ||
| L Lat Vent | 6.0 ± 5.4 | 10.3 ± 11.1 | 5.0 ± 4.8 | 5.6 ± 4.2 | 2.0 | 0.12 | 3.3 | 0.07 | 2.4 | 0.12 | 1.4 | |
| R Lat Vent | 6.3 ± 7.8 | 9.5 ± 7.1 | 7.2 ± 5.8 | 7.3 ± 5.6 | 0.6 | 0.2 | 1.1 | 0.9 | ||||
| L thalamus | 13.9 ± 5.6 | 12.0 ± 8.8 | 14.9 ± 7.4 | 9.2 ± 5.9 | 2.5 | 0.06 | 0.3 | 5.2 | 0.03 | 1.3 | ||
| R thalamus | 13.1 ± 5.9 | 13.7 ± 8.2 | 15.2 ± 7.1 | 10.3 ± 6.0 | 1.7 | 0.2 | 1.7 | 2.8 | 0.10 | |||
| L hippocampus | 6.7 ± 5.1 | 18.7 ± 14.7 | 7.4 ± 5.5 | 10.3 ± 6.8 | 6.5 | 0.001 | 3.7 | 0.06 | 13.8 | 0.0004 | 5.2 | 0.03 |
| R hippocampus | 6.1 ± 4.3 | 13.6 ± 10.2 | 9.7 ± 4.3 | 9.2 ± 8.2 | 3.0 | 0.04 | 0.1 | 4.2 | 0.05 | 5.4 | 0.02 | |
| L amygdala | 11.8 ± 8.6 | 12.5 ± 9.7 | 15.4 ± 9.1 | 13.1 ± 14.2 | 0.4 | 0.6 | 0.1 | 0.3 | ||||
| R amygdala | 12.6 ± 8.1 | 12.1 ± 7.2 | 15.1 ± 12.1 | 13.8 ± 15.2 | 0.2 | 0.6 | 0.1 | 0.1 | ||||
| L caudate | 6.6 ± 6.1 | 7.4 ± 5.6 | 7.5 ± 6.6 | 6.2 ± 6.1 | 0.2 | 0.1 | 0.1 | 0.5 | ||||
| R caudate | 6.3 ± 4.8 | 10.2 ± 8.4 | 5.8 ± 3.8 | 8.9 ± 5.6 | 2.1 | 0.10 | 0.4 | 6.3 | 0.01 | 0.1 | ||
| L putamen | 8.3 ± 5.8 | 17.0 ± 18.0 | 9.6 ± 8.0 | 6.9 ± 4.5 | 3.2 | 0.03 | 3.5 | 0.07 | 1.7 | 6.0 | 0.02 | |
| R putamen | 7.8 ± 6.2 | 15.0 ± 11.3 | 9.3 ± 7.5 | 6.0 ± 4.6 | 4.2 | 0.01 | 4.4 | 0.04 | 1.2 | 8.6 | 0.005 | |
| L pallidum | 20.1 ± 10.5 | 21.0 ± 13.7 | 16.7 ± 10.6 | 12.5 ± 12.1 | 1.9 | 0.13 | 4.4 | 0.04 | 0.3 | 0.8 | ||
| R pallidum | 18.3 ± 15.8 | 4.3 ± 4.8 | 11.5 ± 10.1 | 17.6 ± 16.1 | 3.7 | 0.02 | 1.0 | 1.5 | 9.7 | 0.003 | ||
| L accumbens area | 23.1 ± 17.4 | 45.1 ± 51.5 | 24.4 ± 22.2 | 18.0 ± 16.9 | 2.7 | 0.06 | 3.6 | 0.06 | 1.3 | 4.3 | 0.04 | |
| R accumbens area | 24.8 ± 20.0 | 64.9 ± 49.6 | 31.1 ± 28.1 | 17.5 ± 21.6 | 7.2 | 0.0003 | 7.9 | 0.01 | 3.3 | 0.07 | 13.5 | 0.0005 |
Notes: Test statistics are given for the ANOVA model fitting each subject’s PCVD by the factors group (alcoholic, control), sex (male, female), and their interaction. (P-values greater than 0.15 are not shown.) For the directional shown.) For the directional PCVD, positive values indicate the CMA volume estimate is larger than the FreeSurfer volume estimate.
Abbreviations: CMA, Center for Morphometric Analysis; PCVD, percent common volume difference.