. Author manuscript; available in PMC: 2011 Mar 14.

Published in final edited form as: Mol Ther. 2008 Aug 19;16(10):1710–1718. doi: 10.1038/mt.2008.166

Table 2.

Transduction characteristics of novel AAV vectors after lateral ventricle injections into neonatal mouse brain

	Score in select brain regions

Capsid (clade)	Olfactory bulb	Prefrontal cortex	Striatum	Cortex	Rostral hippocampus	Caudal hippocampus	Thalamus	Amygdala	Mammillary bodies	Hypothalamus
hu.48R2 (A)	++^a ^b_{n = 2}	++_{n = 2}	++_{n = 2}	++_{n = 1} +++_{n = 1}	++_{n = 2}	++_{n = 1} +++_{n = 1}	++_{n = 2}	++_{n = 2}	+_{n = 2}	+_{n = 2}
hu.48R3 (A)	++_{n = 1} +++_{n = 1}	++_{n = 2}	+_{n = 1} ++_{n = 1}	++_{n = 2}	++_{n = 2}	+_{n = 1} ++_{n = 1}	+_{n = 1} ++_{n = 1}	++_{n = 2}	+_{n = 1} ++_{n = 1}	+_{n = 1} ++_{n = 1}
hu.44R3 (A)	+_{n = 1} ++_{n = 1}	++_{n = 2}	−_{n = 1} +_{n = 1}	+_{n = 2}	++_{n = 2}	++_{n = 2}	++_{n = 2}	−_{n = 1} +_{n = 1}	−_{n = 1} +_{n = 1}	+_{n = 2}
hu.29R (B)	++_{n = 3}	++_{n = 3}	+_{n = 1} ++_{n = 2}	++_{n = 3}	+_{n = 3}	+_{n = 3}	−_{n = 2} +_{n = 1}	−_{n = 1} +_{n = 1} ++_{n = 1}	−_{n = 2} +_{n = 1}	−_{n = 3}
hu.11 (C)	++_{n = 2}	++_{n = 2}	+n = 2	++_{n = 1} +++_{n = 1}	++_{n = 2}	++_{n = 2}	+_{n = 2}	++_{n = 1}	++_{n = 2}	+_{n = 2}
cy.5R1 (D)	++_{n = 1} +++_{n = 1}	++_{n = 2}	++_{n = 2}	++_{n = 1} +++_{n = 1}	++_{n = 2}	++_{n = 2}	+_{n = 1} ++_{n = 1}	++_{n = 2}	+_{n = 2}	+_{n = 2}
cy.5R4 (D)	++_{n = 2}	++_{n = 2}	++_{n = 2}	++_{n = 2}	++_{n = 2}	++_{n = 2}	+_{n = 2}	++_{n = 1} +++_{n = 1}	+_{n = 2}	−_{n = 2}
hu.37 (E)	++_{n = 2}	++_{n = 2}	++_{n = 2}	+++_{n = 2}	++_{n = 2}	++_{n = 2}	+_{n = 2}	++_{n = 2}	+_{n = 1} +++_{n = 1}	+_{n = 1} ++_{n = 1}
rh.10 (E)	++_{n = 3}	++_{n = 3}	+_{n = 1} ++_{n = 2}	++_{n = 3}	++_{n = 3}	++_{n = 3}	+_{n = 3}	++_{n = 1} +++_{n = 1}	−_{n = 2} +_{n = 1}	−_{n = 3}
pi.2 (E)	++_{n = 1} +++_{n = 1}	++_{n = 2}	+_{n = 2}	++_{n = 2}	+++_{n = 1}	++_{n = 3}	++_{n = 3}	+_{n = 1} ++_{n = 2}	++_{n = 2} +++_{n = 1}	++_{n = 2} +++_{n = 1}
rh.64R1 (E)	++_{n = 1} +++_{n = 1}	++_{n = 2}	+_{n = 2}	++_{n = 1} +++_{n = 1}	++_{n = 2}	++_{n = 2}	+_{n = 2}	++_{n = 3}	+_{n = 2}	+_{n = 2}
rh.64R2 (E)	+++_{n = 2}	++_{n = 2}	−_{n = 1} ++_{n = 1}	++_{n = 1} +++_{n = 1}	++_{n = 2}	++_{n = 2}	+_{n = 2}	++_{n = 2}	−_{n = 2}	−_{n = 2}
rh.43 (E)	++_{n = 3}	+_{n = 1} ++_{n = 2}	+_{n = 2} ++_{n = 1}	++_{n = 2} +++_{n = 1}	++_{n = 3}	+_{n = 1} ++_{n = 2}	+_{n = 2} ++_{n = 1}	+++_{n = 2}	−_{n = 3}	−_{n = 3}
rh.2R (E)	++_{n = 2} +++_{n = 1}	++_{n = 3}	+_{n = 2} ++_{n = 1}	++_{n = 2} +++_{n = 1}	++_{n = 3}	++_{n = 3}	+_{n = 2} ++_{n = 1}	++_{n = 2} +++_{n = 1}	−_{n = 2} +_{n = 1}	−_{n = 2} +_{n = 1}
hu.32 (F)	+++_{n = 2}	++_{n = 2}	++_{n = 2}	+++_{n = 2}	++_{n = 2}	++_{n = 2}	++_{n = 2}	+_{n = 2} ++_{n = 1}	++_{n = 1} +++_{n = 1}	++_{n = 2}
AAV9 (F)	++_{n = 1} +++_{n = 2}	++_{n = 2} ++_{n =1}	++_{n = 2} +++_{n 1}	++_{n = 2} +++_{n = 1}	++_{n = 3}	+++_{n = 3}	++_{n = 2}	++_{n = 2}	+_{n = 2} ++_{n = 1}	+_{n = 2} ++_{n =} 1
rh.8 (other)	++_{n = 2} +++_{n = 1}	++_{n = 3}	++_{n = 3}	++_{n = 3}	++_{n = 3}	++_{n = 3}	++_{n = 3}	+_{n = 1} ++_{n = 2}	+_{n = 2} ++_{n = 1}	+_{n = 2} ++_{n = 1}
rh.32.33 (other)	++_{n = 2}	++_{n = 2}	++_{n = 2}	++_{n = 2}	++_{n = 2}	++_{n = 2}	++_{n = 2}	++_{n = 2}	−_{n = 2}	−_{n = 2}

Abbreviation: AAV, adeno-associated virus.

Scoring: (−) no transduction, (+) very few positive cells, (++) many positive cells, and (+++) region is completely saturated with ISH-positive cells.

The number of animals (n) with the particular score is given to the right of the score.