Table 3. Diabetic Nephropathy Candidate Loci.
GWAS, Replication, and Combined (GWAS+Replication) P values for diabetic nephropathy candidate loci across the genome.
MAF: Minor Allele Frequency. OR: Odds Ratio. 95% CI: 95% Confidence Interval.
| Locus |
GWAS T2DM-ESRD (n=965) Controls (n=1029) |
Replication T2DM-ESRD (n=709) Controls (n=690) |
Combined T2DM-ESRD (n=1674) Controls (n=1719) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Marker | Chr | Position | Nearest Gene(s) |
Minor Allele (Major Allele) |
MAF T2DM- ESRD |
MAF Control |
Additive P value |
MAF T2DM- ESRD |
MAF Control |
Additive P value |
Additive P value |
OR (95% CI) |
| rs10888287 | 1 | 246,184,039 | OR2L13 | G(T) | 0.439 | 0.503 | 5.03E-04 | 0.444 | 0.495 | 0.0482 | 5.97E-05 | 0.82 (0.75–0.90) |
| rs4260465 | 3 | 164,231,046 | No gene | G(C) | 0.364 | 0.414 | 4.31E-04 | 0.381 | 0.421 | 0.0382 | 4.50E-05 | 0.81 (0.74–0.90) |
| rs11730446 | 4 | 96,382,267 | UNC5C | G(A) | 0.459 | 0.403 | 6.23E-04 | 0.459 | 0.424 | 0.0465 | 1.24E-04 | 1.21 (1.10–1.33) |
| rs891382 | 4 | 147,371,790 | SLC10A7/LSM6 | G(A) | 0.085 | 0.059 | 3.19E-04 | 0.081 | 0.065 | 0.0183 | 2.42E-05 | 1.49 (1.24–1.80) |
| rs7697691 | 4 | 182,853,951 | No gene | G(A) | 0.243 | 0.285 | 0.0016 | 0.243 | 0.285 | 0.0127 | 7.37E-05 | 0.80 (0.72–0.89) |
| rs3822908 | 6 | 97,706,333 | C6orf167 | C(T) | 0.125 | 0.162 | 3.63E-04 | 0.121 | 0.147 | 0.0462 | 4.52E-05 | 0.75 (0.65–0.86) |
| rs7760831 | 6 | 102,071,536 | GRIK2 | C(T) | 0.176 | 0.222 | 2.55E-04 | 0.193 | 0.224 | 0.0455 | 3.48E-05 | 0.77 (0.69–0.87) |
| rs208865 | 6 | 130,114,249 | C6orf191/ARHGAP18 | T(C) | 0.118 | 0.082 | 2.14E-04 | 0.115 | 0.091 | 0.0364 | 2.90E-05 | 1.41 (1.20–1.66) |
| rs9493454 | 6 | 133,186,322 | RPS12 | C(A) | 0.439 | 0.376 | 4.91E-04 | 0.453 | 0.395 | 0.0089 | 1.72E-05 | 1.24 (1.13–1.37) |
| rs7769051 | 6 | 133,188,489 | RPS12 | A(C) | 0.349 | 0.289 | 4.06E-04 | 0.362 | 0.3 | 0.0012 | 2.20E-06 | 1.28 (1.16–1.42) |
| rs6930576 | 6 | 148,746,647 | SASH1 | A(G) | 0.337 | 0.276 | 1.87E-05 | 0.319 | 0.274 | 0.0099 | 7.04E-07 | 1.31 (1.18–1.45) |
| rs773506 | 9 | 93,015,292 | AUH | A(G) | 0.179 | 0.233 | 3.27E-04 | 0.174 | 0.223 | 0.0130 | 6.45E-06 | 0.76 (0.67–0.85) |
| rs11175885 | 12 | 64,400,897 | C12orf66/TMEM5 | G(A) | 0.181 | 0.234 | 0.0013 | 0.19 | 0.249 | 0.0106 | 2.18E-05 | 0.77 (0.68–0.87) |
| rs2358944 | 12 | 64,403,825 | MSRB3/HMGA2 | A(G) | 0.178 | 0.232 | 9.48E-04 | 0.188 | 0.256 | 0.0018 | 3.54E-06 | 0.75 (0.67–0.85) |
| rs2904532 | 12 | 65,582,311 | GRIP1/CAND1 | G(A) | 0.141 | 0.183 | 8.17E-04 | 0.148 | 0.184 | 0.0172 | 4.87E-05 | 0.76 (0.67–0.87) |
| rs11176482 | 12 | 65,582,814 | GRIP1/CAND1 | C(T) | 0.141 | 0.184 | 7.08E-04 | 0.147 | 0.182 | 0.0202 | 4.79E-05 | 0.76 (0.67–0.87) |
| rs12302041 | 12 | 76,654,356 | NAV3 | A(G) | 0.085 | 0.055 | 3.09E-04 | 0.088 | 0.06 | 0.0149 | 1.15E-05 | 1.54 (1.27–1.87) |
| rs1978243 | 14 | 86,596,160 | No gene | T(C) | 0.22 | 0.274 | 7.53E-04 | 0.221 | 0.274 | 0.0105 | 1.61E-05 | 0.78 (0.70–0.87) |
| rs6494387 | 15 | 61,132,579 | TPM1 | A(G) | 0.367 | 0.311 | 2.32E-04 | 0.358 | 0.32 | 0.0209 | 1.80E-05 | 1.25 (1.13–1.39) |
| rs1034589 | 22 | 29,909,233 | RNF185 | C(T) | 0.036 | 0.062 | 0.0010 | 0.033 | 0.065 | 0.0055 | 1.06E-05 | 0.59 (0.46–0.74) |
| rs2106294 | 22 | 29,975,759 | LIMK2 | C(T) | 0.035 | 0.062 | 7.49E-04 | 0.031 | 0.064 | 0.0028 | 4.11E-06 | 0.57 (0.45–0.72) |
| rs4820043 | 22 | 29,977,094 | LIMK2 | A(G) | 0.036 | 0.062 | 0.0010 | 0.031 | 0.065 | 0.0026 | 5.07E-06 | 0.57 (0.45–0.73) |
| rs5749286 | 22 | 30,230,359 | SFI1 | A(C) | 0.038 | 0.065 | 0.0013 | 0.036 | 0.068 | 0.0030 | 9.79E-06 | 0.60 (0.47–0.75) |
| rs16996381 | 22 | 34,841,225 | APOL3 | G(A) | 0.336 | 0.391 | 0.0018 | 0.371 | 0.432 | 0.0191 | 1.06E-04 | 0.82 (0.75–0.91) |
| rs735853 | 22 | 35,009,161 | MYH9 | G(C) | 0.082 | 0.123 | 4.59E-04 | 0.079 | 0.118 | 0.0091 | 1.20E-05 | 0.69 (0.59–0.82) |