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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Trends Immunol. 2011 Jan 19;32(2):73–79. doi: 10.1016/j.it.2010.12.007

Figure 1.

Figure 1

NOD2 activates the autophagy pathway. Bacteria is engaged by NOD2 and functions to recruit ATG16L1 to the plasma membrane. The interaction of NOD2 and ATG16L1 leads to the formation of autophagosome. The fusion of the autophagosome with the lysosome promotes the processing/loading of bacterial peptide onto MHC II molecule. The peptide-MHC II complex leads to appropriate T cell activation and bacteria clearance. Consistent with the role of NOD2 induction of autophagy is the finding that NOD2 mutation fails to induce autophagy.