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NOD2 functions in T cells and macrophages (Mθ). TCR and CD28 signaling triggers the activation of NOD2. In T cells, NOD2 interacts with NF-kB inducing kinase (NIK) and c-Rel to form a complex that promotes c-Rel nuclear accumulation. The molecular mechanisms that link TCR, CD28 and NOD2 are unknown. Similarly, it is unclear whether NOD2 function in T cells is exclusive to CD28 or is shared by other costimulatory molecules.
