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Fig. 4. The common usage of the D element in VH and VHH: a genomic D element (camD4) is flanked at both sides with the RSS containing a nonamer (N) separated from a heptamer (H) by a 12-nt spacer. The sequences derived from the germline camD4 (upper line), VH-cDNA clone i5h50 (middle line) and VHH-cDNA clone med83 (lower line) are boxed. The CDR3 region between the FR3 and FR4 is indicated.
