mTORC1 is Selectively Impaired in the Rheb1f/f, Nes-cre KO Brain.
(A) Western blots show a drastic reduction in mTORC1 activity in the 4-wk old Rheb1f/f, Nes-cre (hereafter, KO) brain while the total level of S6 is not altered.
(B) Western blots show significant upregulation of mTORC2 activity in the 4-wk old Rheb1 KO brain and concurrent upregulation of the activity of signaling components upstream of Rheb1 (pAKT308 and pTSC2).