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. Author manuscript; available in PMC: 2011 Mar 14.
Published in final edited form as: Biol Psychiatry. 2009 Jan 15;65(9):760–769. doi: 10.1016/j.biopsych.2008.11.028

Figure 5. Exposure to an adverse caregiving environment had no effect on Reelin gene expression or methylation of Reelin DNA.

Figure 5

(A) Maltreatment or cross-fostered care during infancy had no detectable effect on Reelin mRNA levels in the adult prefrontal cortex (n=8–10/group). Male and female adults were derived from 5 mothers. (B) Schematic of the large CpG island (in grey) relative to the transcription start site (TSS) of the Reelin gene (note that the entire CpG island is not represented, but only the portion relevant to the primer target region). Methylated primer pair positions are indicated by the left and right arrows, and primer sequences can be found in Supplementary Table 1. (C) Exposure to the maltreatment condition had no observable effect on methylation of Reelin DNA within the prefrontal cortex. We also observed no changes in methylation of a CpG island located within an intragenic region of the Reelin gene (at location 2841591–2841823; data not shown). Male and female subjects were derived from 13 mothers; n=4–8/group. For panels A and C, error bars represent SEM. PN=postnatal day.