Vps10p is mislocalized in ric1Δ
cells. Wild-type (WT, SEY6210) and
ric1Δ (GPY1408) cells were grown at 30°C, converted
to spheroplasts, and subjected to differential centrifugation. S2 and
P2 are, respectively, the supernatant and pellet fractions from
centrifugation at 10,000 × g for 15 min.; S3 and
P3 are, respectively, the supernatant and pellet fractions from
centrifugation at 200,00 × g for 17 min. Pellets
were resuspended in volumes equal to the supernatants, and equal
volumes were analyzed by SDS-PAGE and immunoblotting.