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. Author manuscript; available in PMC: 2011 Mar 14.
Published in final edited form as: Proc West Pharmacol Soc. 2007;50:58–60.

Figure 1. P2Y Receptor Mediated Angiogenesis Utilizes VEGFR2 Signaling.

Figure 1

Inhibition of VEGFR2 intracellular signaling by SU1498 (1 μM) suppressed the pro-angiogenic potential of P2Y1/2 receptor agonists (ATP and 2MS-ATP) during a 24 h tubulogenesis assay. Control mean = 979.4 ± 403.6 angiogenesis units. Control consisted of CD31+ cells incubated in CDMEM supplemented with 2% FBS and 0.01% DMSO. The angiogenic stimulation control used was endothelial growth media-2 (EGM-2) containing VEGF.