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. Author manuscript; available in PMC: 2011 Mar 14.
Published in final edited form as: Proc West Pharmacol Soc. 2007;50:58–60.

Figure 2. Putative Role of NDPK-B and P2Y Receptor Activation in Tumor Angiogenesis.

Figure 2

We have observed breast cancer-secreted NDPK-B to be a significant contributor to promoting angiogenesis (ref). Extracellular NDPK would modulate nucleotides such as elevating ATP levels. This scenario would subsequently lead to P2Y purinergic receptor activation above an unknown threshold to produce conditions favorable to pathological angiogenesis. Our current data suggests that this P2Y angiogenic signaling promotes tumor angiogenesis in concert with established VEGF angiogenic signal.