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. Author manuscript; available in PMC: 2011 Nov 4.
Published in final edited form as: Neuron. 2010 Nov 4;68(3):409–427. doi: 10.1016/j.neuron.2010.09.043

Figure 10. Vascular-Mediated Neurodegeneration Following Pericyte Loss.

Figure 10

PDGFRβ deficient signaling in brain pericytes leads to a progressive age-dependent pericyte loss resulting in (1) reductions in brain microcirculation with diminished cerebral blood flow (CBF) and CBF responses to a stimulus (CBF dysregulation) leading to a chronic perfusion stress and hypoxia, and (2) blood-brain barrier breakdown with accumulation of serum proteins and several cytotoxic and neurotoxic pathologic deposits in brain. Both, arms 1 and 2 may contribute to secondary neuronal injury and neurodegeneration mediated by a neurovascular insult.