Table 1.
Classification of substances that influence endocannabinoid system
| Cannabinoid receptor agonists | ||
|---|---|---|
| Classical cannabinoids | delta9 THC | partial agonist of CB1R and CB2R |
| HU 210 | complete agonist of both CB1R and CB2R | |
| Non–classical cannabinoids | CP–55, 940 | complete agonist of both CB1R and CB2R |
| Specific CB–2 receptor agonist | AM 1241 | |
| Aminoalkylindoles | WIN–55, 212–2 | complete agonist of both CB1R and CB2R, slightly selective for CB2R |
| Eicosanoids | Anandamide (AEA) R–(+)–methanandamide | partial agonist of both CB1R and CB2R and TRPV1 agonist |
| Met F AEA 2–AG | full agonist of both CB1R and CB2R | |
| Cannabinoid receptor antagonists/inverse agonists | ||
| Diarylpyrazoles and other derivatives | SR141716A [rimonabant], AM 251, AM281 | selective CB1R blockers |
| SR144528, AM 630 | selective CB2R blockers | |
| Uptake blockers: AM 404 | ||
| FAAH inhibitors: PMSF, URB 597 |