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. Author manuscript; available in PMC: 2011 Mar 14.
Published in final edited form as: Biochem Biophys Res Commun. 2010 Jul 17;399(2):117–122. doi: 10.1016/j.bbrc.2010.07.009

Fig. 4.

Fig. 4

miR-126-24G induces much less translational repression than miR-126-24A. (A) Positions of the predicted (Pictar) miR-126 target sequences are marked (X) in the 3′UTRs of human IRS-1 mRNAs. (B) Expression of the Lenilla luciferase reporter is significantly reduced when IRS1-UTR reporter vectors, containing the miR-126 binding site is cotransfected together with miR-126-24A. This reduction is not observed when miR-126-24G or control expression vectors are used (left panel) (n =3; ** indicates p < 0.05.). While, That shows no significant difference between miR-126-24A, miR-126-24G and control, when psiceck-two control vectors is cotransfected (right panel). The vertical axis indicates the Renilla/firefly luciferase ratio.