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In the occipital cortex, ceruloplasmin was localized to pyramidal neurons (arrows) in the cases of DKA/BE (B), while in controls (ages 9, 16 years) ceruloplasmin was not found to be increased in the neuronal cell bodies (A). Of interest, large neuronal cells in the occipital cortex from the DKA/BE cases showed the highest level of ceruloplasmin (B, arrowheads). Scale bar = 50 μm.
