Table 1.

Hematologic parameters in wt, Hfe-KO, and Hamp-KO female mice

	Hb, g/dL	RBC, ×106/μL	Hct, %	MCV, fL	MCH, pg	Retic, ×109/L	LIC, μg/mg dry	SI, μg/dL	Tf Sat, %
wt (2 months)	15.5 ± 0.3	9.8 ± 0.5	47.0 ± 0.7	45.9 ± 0.3	15.2 ± 0.1	285 ± 14	0.29 ± 0.04	121 ± 39	53 ± 11
wt (5 months)	15.4 ± 0.2	10.0 ± 0.1	44.4 ± 0.5	44.3 ± 0.4	15.3 ± 0.1	246 ± 15	0.41 ± 0.09	123 ± 15	58 ± 14
wt (12 months)	15.2 ± 0.2	11.0 ± 0.1	49.7 ± 0.9	45.2 ± 0.6	13.9 ± 0.2	377 ± 28	0.43 ± 0.09	153 ± 25	53 ± 14
Hfe-KO (2 months)	16.6 ± 0.2†	10.2 ± 0.1	48.8 ± 0.7	48.2 ± 0.3†	16.4 ± 0.1‡	310 ± 10	1.36 ± 0.32‡	219 ± 20*	89 ± 14*
Hfe-KO (5 months)	16.2 ± 0.3*	9.8 ± 0.2	46.9 ± 0.6†	47.9 ± 0.5†	16.5 ± 0.2‡	260 ± 17	1.59 ± 0.25‡	233 ± 20†	91 ± 14†
Hfe-KO (12 months)	15.7 ± 0.3	9.9 ± 0.2†	47.3 ± 0.7*	48.2 ± 0.7†	16.0 ± 0.3‡	260 ± 35*	1.87 ± 0.25‡	310 ± 10†	86 ± 14‡
Hamp-KO (2 months)	15.7 ± 0.1§	9.9 ± 0.1	46.7 ± 0.5	47.0 ± 0.2*§	15.7 ± 0.2*§	305 ± 75	3.64 ± 0.48†§	NA	NA

Values are mean ± SEM of 5 to 20 female mice.

Hct indicates hematocrit; MCV, mean corpuscular volume; Retic, reticulocyte count; LIC, liver iron concentration; SI, serum iron; Tf Sat, transferrin saturation; and NA, not applicable.

^*P ≤ .05 relative to age-matched wt controls.

^†P ≤ .01 relative to age-matched wt controls.

^‡P ≤ .001 relative to age-matched wt controls.

^§P ≤ .05 relative to 2-month-old Hfe-KO mice.