Table 2.

Hematologic parameters in bone marrow transplanted animals

	Hb, g/dL	RBC, ×106/μL	Hct, %	MCV, fL	MCH, pg	Retic, ×109/L	LIC, μg/mg dry	SIC, μg/mg dry	SI, μg/dL	Tf Sat, %
Wt → wt	14.3 ± 0.2	10.2 ± 0.2	46.6 ± 0.7	45.7 ± 0.2	14.1 ± 0.1	276 ± 12	0.29 ± 0.02	1.97 ± 0.18	117 ± 10	56 ± 3
Hfe → Hfe	15.3 ± 0.2†	9.7 ± 0.1*	47.8 ± 0.2	49.4 ± 0.8‡	15.8 ± 0.1‡	238 ± 26	0.98 ± 0.08‡	2.47 ± 0.75	225 ± 13‡	88 ± 2†
th3/+ → wt	7.8 ± 0.2	8.0 ± 0.2	29.2 ± 1.0	36.5 ± 1.5	9.7 ± 0.1	1587 ± 76	1.29 ± 0.27	8.22 ± 1.12	162 ± 11	49 ± 4
th3/Hfe → wt	8.1 ± 0.3	8.3 ± 0.2	30.8 ± 1.6	36.7 ± 1.0	9.7 ± 0.2	1807 ± 149	1.08 ± 0.05	10.31 ± 0.74	152 ± 12	51 ± 3
th3/+ → Hfe	9.4 ± 0.1‡	8.9 ± 0.2†	36.9 ± 0.3†	41.6 ± 0.7*	10.6 ± 0.2†	1958 ± 102*	3.09 ± 0.34‡	8.29 ± 1.3	232 ± 7*	82 ± 4†

Values are mean ± SEM of 5 to 20 female mice.

Hct indicates hematocrit; MCV, mean corpuscular volume; Retic, reticulocyte count; LIC, liver iron concentration; SIC, splenic iron concentration; SI, serum iron; and Tf Sat, transferrin saturation.

^*P ≤ .05 relative to controls (wt → wt for Hfe → Hfe and th3 → wt for th3/+ → Hfe).

^†P ≤ .01 relative to controls (wt → wt for Hfe → Hfe and th3 → wt for th3/+ → Hfe).

^‡P ≤ .001 relative to controls (wt → wt for Hfe → Hfe and th3 → wt for th3/+ → Hfe).