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3D density map of HIV Env at 2.0 nm resolution (Liu et al., 2008). Comparison of EM map (D) with simulated maps calculated from three gp120 monomer crystal structures: CD4-binding conformation (A), b12-binding conformation (B), and ligand free conformation (C) indicates that the molecular docking remains challenging at 2.0 nm resolution. The scale bar is 5 nm.
