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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Gastroenterol Clin North Am. 2011 Mar;40(1):45–67. doi: 10.1016/j.gtc.2010.12.011

Figure 1.

Figure 1

Gene-environment paradigm in IBS development. A gene-environment paradigm supports the importance of both genes and environment in the development of IBS for both familial and sporadic IBS. A number of combinations of individual genetic and environmental risk factors are possible, with each specific combination resulting in specific alterations in gastrointestinal motor and sensory function, and ultimately symptom presentation and the final clinical phenotype.