TABLE 3.
Trabecular bone parameters in the distal femur of 5-6 month old male WT, HET and KO mice. Measurements include trabecular bone volume per total bone volume (BV/TV), trabecular thickness (TbTh), trabecular spacing (TbSp), osteoblast surface per bone surface (ObS/BS), osteoclast surface per bone surface (OcS/BS), mineral apposition rate (MAR) and bone formation rate per bone surface (BFR/BS).
| Parameter | COX-2 WT | COX-2 HET | COX-2 KO |
|---|---|---|---|
| (A) μCT analysis | |||
| BV/TV (%) | 18.7 ± 0.62 (32) | 18.4 ± 0.87 (31) | 17.5 ± 0.85 (29) |
| TbTh (μm) | 55.5 ± 0.78 (32) | 56.1 ± 0.80 (31) | 54.0 ± 0.94 (29) |
| TbSp (μm) | 207 ± 4.90 (32) | 219 ± 7.69 (31) | 212 ± 7.35 (29) |
| (B) Static histomorphometry analysis | |||
| BV/TV (%) | 7.55 ± 0.30 (31) | 6.82 ± 0.29 (30) | 6.12 ± 0.30 (29)a |
| ObS/BS (%) | 3.10 ± 0.41 (31) | 3.65 ± 0.52 (30) | 2.65 ± 0.26 (29) |
| OcS/BS (%) | 4.63 ± 0.67 (31) | 4.90 ± 0.64 (30) | 5.60 ± 0.88 (29) |
| (C) Dynamic histomorphometry analysis | |||
| MAR (μm/d) | 0.79 ± 0.05 (27) | 0.73 ± 0.05 (26) | 0.79 ± 0.04 (25) |
| BFR/BS (μm3/μm2/d) | 0.22 ± 0.02 (27) | 0.20 ± 0.02 (26) | 0.22 ± 0.02 (25) |
Data are means ± SEM for the number of mice in parentheses. Data are means ± SEM for the number of mice in parentheses.
a
Significantly different from WT, p<0.01.