. Author manuscript; available in PMC: 2011 Aug 1.

Published in final edited form as: Bone. 2010 May 13;47(2):341–352. doi: 10.1016/j.bone.2010.05.006

TABLE 5.

Serum markers of bone turnover in 6-month old male COX-2 WT and KO mice injected with PTH (80 μg/kg) or vehicle for 22 days. Measurements were made on serum obtained 3 h after the last PTH injection.

Parameter	COX-2 WT		COX-2 KO

	Vehicle	PTH	Vehicle	PTH
Formation Markers
P1NP (ng/ml)	54.9±7.7	116.3±6.5^a	75.3±4.0^b	215.6±33.2^a^,^b
Osteocalcin (U/L)	27.2±3.9	86.0±8.0^a	38.3±4.7	168.5±17.70^a^,^b
Resorption Markers
CTX (ng/ml)	15.0±1.9	20.6±2.9	22.9±4.0^c	47.1±73.2^a^,^b
TRAP 5b (U/L)	4.4±0.4	13.8±1.30^a	5.4±0.6	20.6±2.9^a^,^b

Data are means ± SEM for n=11-13 mice.

Significant effect of PTH, p<0.01.

Significant effect of genotype, p<0.01;

p<0.05.