Figure 6.

p300 conditional knock-out mice show impaired long-term contextual fear memory and normal cued fear memory. (A) p300 conditional knock-out mice (n = 10) show identical percentage of freezing compared to their control littermates (n = 10) when tested 1 h after training in the cued fear conditioning. (B) p300 conditional knock-out mice (n = 12) show a significant lower percentage of freezing compared to their control littermates (n = 12) when tested 24 h after training in the contextual fear conditioning; *P < 0.05. (C) p300 conditional knock-out mice (n = 8) show an identical percentage of freezing compared to their control littermates (n = 10) when tested 24 h after training in the cued fear conditioning. cKO, p300 conditional knock-out; Ct, control littermate.