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. Author manuscript; available in PMC: 2011 Mar 14.
Published in final edited form as: Biochem J. 2009 Apr 15;419(2):377–385. doi: 10.1042/BJ20082082

Figure 5. S1517K and L1521K substitutions abolished BTX action on the cockroach BgNav sodium channels.

Figure 5

(A and B) Sodium current traces from wild-type (A) and L1521K (B) sodium channels elicited, after 3000 repetitive pulses at a frequency of 10 Hz, by a 20-ms test pulse to −10 mV from a holding potential of −120 mV before and after the application of 500 nM BTX. (C and D) Curves of voltage-dependence of activation of wild-type (C) and L1521K (D) sodium channels. (E and F) Curves of steady-state inactivation of wild-type (E) and L1521K (F) sodium channels. (G) Percentages of non-inactivating current induced by BTX in wild-type (WT) and mutant sodium channels. (H) Percentages of tail current induced by BTX in wild-type (WT) and mutant sodium channels.