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. Author manuscript; available in PMC: 2011 Mar 14.
Published in final edited form as: Biochem J. 2009 Apr 15;419(2):377–385. doi: 10.1042/BJ20082082

Figure 6. A Kv 1.2-based model of the cockroach BgNav sodium channel in the open state.

Figure 6

The helices are shown as follows: IIIS6, red rod; IIS4–IIS5 and IIS5, green rods; pore helices, green cylinders; IS6, IIS6 and IVS6, red strands; linkers IIS4–IIS5 and IIS5 in domains I, III and IV, green strands. The side chains Ile1514, Gly1516, Phe1518 and Asn1522 in IIIS6, which were shown to be required for normal pyrethroid action in the present study, are space-filled. Sticks show side chains Met918 in the IIS4–IIS5 linker, Leu925, Thr929 and Leu932 in IIS5 (housefly sodium channel) and Phe1519 in IIIS6 (cockroach sodium channel) identified previously to be required for pyrethroid action and/or binding [6–8]. (A) Cytoplasmic view. (B) Side view. (C) View along the P-helix in domain II. (D) Enlarged view of (B) with the cluster of putative pyrethroid-interacting residues.