Table 1. Gating properties of 33 functional DmNav variants.
Variant | Activation | Inactivation | ||
---|---|---|---|---|
V1/2 (mV) | k (mV) | V1/2 (mV) | k (mV) | |
DmNaV19 | −6.7±0.5 | 5.2±0.2 | −50.1±0.3 | 6.3±0.1 |
DmNaV15 | −11.4±0.6 | 7.3±0.2 | −34.9±0.9 | 5.5±0.3 |
DmNaV1-6 | −12.0±2.1 | 9.8±0.7 | −49.9±0.5 | 5.6±0.9 |
DmNaV13-2 | −15.5±0.4 | 8.2±0.3 | −45.5±0.4 | 7.5±0.2 |
DmNaV1-3 | −16.2±0.5 | 8.0±0.2 | −42.3±0.6 | 7.3±0.6 |
DmNaV2-3 | −20.5±1.6 | 8.0±0.5 | −46.7±0.2 | 4.8±0.2 |
DmNaV2-2 | −20.6±0.4 | 7.4±0.2 | −39.8±0.4 | 6.1±0.2 |
DmNaV4-1 | −21.6±0.5 | 6.3±0.2 | −41.1±0.2 | 5.2±0.1 |
DmNaV3-1 | −22.6±0.9 | 6.6±0.4 | −46.4±0.4 | 5.0±0.1 |
DmNaV17 | −23.1±1.0 | 7.0±0.3 | −47.4±0.6 | 5.1±0.2 |
DmNaV28 | −23.3±0.8 | 5.5±0.3 | −39.9±0.5 | 5.4±0.2 |
DmNaV3-2 | −23.4±0.5 | 6.4±0.2 | −43.8±0.4 | 5.4±0.1 |
DmNaV1-2 | −23.4±0.8 | 7.5±0.3 | −45.1±0.4 | 5.5±0.1 |
DmNaV26 | −23.6±0.5 | 3.7±0.2 | −39.7±0.2 | 4.4±0.1 |
DmNaV10-2 | −23.7±0.6 | 4.5±0.2 | −40.1±0.3 | 4.5±0.2 |
DmNaV2-1 | −23.8±0.9 | 6.7±0.2 | −48.3±0.5 | 5.3±0.1 |
DmNaV1-1 | −24.6±0.8 | 7.6±0.3 | −47.3±0.3 | 5.6±0.1 |
DmNaV23 | −24.9±0.7 | 6.6±0.4 | −46.1±0.4 | 5.2±0.1 |
DmNaV13-1 | −25.3±0.9 | 4.7±0.3 | −42.9±0.3 | 4.8±0.1 |
DmNaV2-4 | −25.7±0.6 | 5.6±0.4 | −46.1±0.8 | 4.9±0.1 |
DmNaV29 | −25.9±1.2 | 4.0±0.3 | −38.9±0.3 | 4.8±0.1 |
DmNaV14 | −26.0±0.7 | 3.0±0.1 | −32.1±0.3 | 4.0±0.1 |
DmNaV5-3 | −26.1±0.9 | 5.9±0.3 | −35.1±0.6 | 4.9±0.1 |
DmNaV20 | −26.2±0.9 | 5.0±0.3 | −45.1±0.3 | 4.9±0.1 |
DmNaV1-5 | −26.7±0.8 | 4.9±0.2 | −43.5±0.2 | 4.8±0.1 |
DmNaV10-1 | −26.9±1.1 | 8.1±0.7 | −44.8±1.1 | 4.8±0.8 |
DmNaV1-4 | −27.2±0.7 | 5.8±0.2 | −45.2±0.4 | 5.4±0.0 |
DmNaV24 | −27.2±0.8 | 4.9±0.2 | −41.9±0.6 | 5.0±0.1 |
DmNaV22 | −28.4±1.1 | 4.6±0.2 | −42.0±0.3 | 5.0±0.1 |
DmNaV27 | −29.1±0.6 | 3.6±0.2 | −42.9±0.4 | 4.5±0.1 |
DmNaV5-2 | −29.5±0.7 | 10.4±0.4 | −49.2±0.5 | 6.5±0.3 |
DmNaV5-1 | −37.1±0.6 | 3.4±0.1 | −44.4±0.7 | 4.5±0.1 |
DmNaV7-1 | −47.7±0.6 | 6.3±0.2 | −66.4±0.2 | 4.5±0.0 |
Note: A minimum of eight oocytes was used to calculate V1/2 and SEM values.