Table 2. Common and unique amino acid changes in five DmNa_V variants.

DmNaV1-1	DmNaV7-1	DmNaV5-1	DmNaV19	DmNaV1-6	n.t. Δ	Location
	R52Q	R52Q	R52Q		g–a*	N term.
E299Q	E299Q	E299Q	E299Q	E299Q	g–c	IS5–S6
Q471R	Q471R				a–g*	L1
		R1296Q	R1296Q		g–a*	L2
		D1300N	D1300N		g–a*	IIIS1
L1363F	L1363F	L1363F	L1363F	L1363F	g–c	IIIS2–S3
I1661V	I1661V	I1661V			a–g	IVS2
	I1670M	I1670M			a–g	IVS2
I1679V		I1679V		I1679V	a–g	IVS3
I1691V	I1691V	I1691V		I1691V	a–g	IVS3
N1822S		N1822S		N1822S	a–g	IVS5–S6
	I260T				t–c	IS4–S5
		I260V			a–g	IS4–S5
	K303R				a–g	IS5–S6
	W319R				t–c	IS5–S6
				R437K	g–a	L1
L486P					t–c	L1
		H487N			c–a	L1
		D656G			a–g	L1
M846V					a–g	IIS1–S2
				A859T	g–a	IIS2
				F885L	t–c	IIS3
			S922P		t–c	IIS4
V1420A					t–c	IIIS4–S5
				V1436A	t–c	IIIS5
			Q1450R		a–g	IIIS5
				N1463Y	a–t	IIIS5–S6
		I1519V			a–g	IIIS5–S6
			S1587N		g–a*	L3
	H1676R				a–g	IVS2–S3
	A1731V				c–t	IVS3
		H1772Y			c–t	IVS5

Note: Amino acid sequences of these variants were compared with the GenBank sequence (Genbank accession number: M32078). Nucleotide bases that correspond to these in the DmNa_V genomic sequence (FlyBase ID FBgn 003036) are in bold. Asterisks (*) represent the RNA editing events identified by Palladino et al. (2000). L1, L2, and L3 represent the three intracellular linkers connecting domains I and II, domains II and III, and domains III and IV, respectively.