Table 2.

Motor and sensory nerve conduction velocities, thermal response latencies, and tactile response thresholds in control and diabetic mice maintained with or without CDC inhibitor treatment (Experiment 2) or fed normal chow or high-fat diet (Experiment 3).

Group	Variable	MNCV	SNCV	Thermal response latency (s)	Tactile response threshold (g)
		EXPERIMENT 2 Baseline (prior to induction of diabetes)
Control		51.2 ± 1.0	37.5 ± 0.3	9.4 ± 0.5	2.18 ± 0.14
		12-wk time point (prior to CDC intervention)
Control		50.2 ± 1.3	38.2 ± 0.4	9.3 ± 0.4	2.23 ± 0.13
Diabetic		40.1 ± 0.9**	32.7 ± 0.85**	18.9 ± 0.6**	0.70 ± 0.1**
		16-wk time point
Control		56.7 ± 1.9	37.8 ± 0.7	11.1 ± 0.5	2.54 ± 0.13
Control +CDC		54.5 ± 1.8	38.1 ± 0.8	11.4 ± 0.4	2.35 ± 0.18
Diabetic		41.2 ± 2.3**	30.4 ± 0.8**	18.0 ± 0.95**	1.23 ± 0.06**
Diabetic+CDC		47.1 ± 2.6**a	34.0 ± 0.5**##	15.3 ± 0.6**##	1.91 ± 0.1**##
		EXPERIMENT 3 Baseline (prior to high-fat diet feeding)
LO+/+, NC		52.3 ± 1.3	36.7 ± 1.6	8.5 ± 0.3	2.31 ± 0.12
LO-/-, NC		52.9 ± 1.4	37.0 ± 1.3	8.1 ± 0.2	2.25 ± 0.13
		16-wk time point
LO+/+, NC		52.7 ± 2.0	36.2 ± 0.9	7.6 ± 0.2	2.36 ± 0.11
LO+/+, HFD		42.4 ± 1.5**	30.5 ± 0.7**	14.3 ± 0.2**	1.22 ± 0.05**
LO-/-, NC		54.5 ± 2.0	36.1 ± 0.5	8.7 ± 0.1	2.34 ± 0.08
LO-/-, HFD		47.5 ± 1.4*, #	34.2 ± 1.3##	14.1 ± 0.3**	1.12 ± 0.04**

Data are expressed as Means ± SEM, n = 8-12 per group.

^*,**p < 0.05 and < 0.01 vs non-diabetic control group (Experiment 2) and vs corresponding groups of mice fed normal chow (Experiment 3).

^#,##p < 0.05 and < 0.01 vs untreated diabetic group (Experiment 2) and vs HFD-fed wild-type mice (Experiment 3).

^a0.0599 vs untreated diabetic group.

NC – normal chow, HFD- high-fat diet.