Table 1.
Patient characteristics
| Discovery cohort (n = 390) | Confirmation cohort (n = 153) | |
|---|---|---|
| Median age at diagnosis, y | 63 | 67 |
| Male sex | 267 (68.5%) | 108 (70.6%) |
| Rai stage at diagnosis | ||
| 0 | 180 (46.3%) | 79 (51.6%) |
| I | 169 (43.4%) | 48 (31.4%) |
| II | 29 (7.5%) | 17 (11.1%) |
| III | 6 (1.5%) | 2 (1.3%) |
| IV | 5 (1.3%) | 7 (4.6%) |
| Missing | 1 | 0 |
| CD38 | ||
| Negative | 234 (71.8%) | 104 (68%) |
| Positive | 92 (28.2) | 49 (32%) |
| Missing | 64 | 0 |
| ZAP-70 | ||
| Negative | 215 (69.1%) | 64 (41.8%) |
| Positive | 96 (30.9%) | 89 (58.2%) |
| Missing | 79 | 0 |
| IGHV | ||
| Mutated | 109 (38.2%) | 70 (56.5%) |
| Unmutated | 176 (61.8%) | 54 (43.5%) |
| Missing | 105 | 29* |
| CD49d | ||
| Negative | 134 (67.3%) | 109 (71.2%) |
| Positive | 65 (32.7%) | 44 (28.8%) |
| Missing | 195 | 0 |
| FISH (prior to treatment) | ||
| 13q− | 126 (40.6%) | 69 (45.1%) |
| Normal | 83 (26.8%) | 36 (23.5%) |
| +12 | 57 (18.4%) | 22 (14.4%) |
| 11q− | 26 (8.4%) | 13 (8.5%) |
| 17p− | 12 (3.9%) | 8 (5.2%) |
| Other | 6 (1.9%) | 5 (3.3%) |
| Missing | 80 | 0 |
| 25 OH vitamin D levels | ||
| Mean (SD) | 30.6 (10.65) | 26.6 (9.27) |
| % insufficient (< 25 ng/mL) | 119 (30.5%) | 61 (39.9%) |
*
IGHV sequencing was attempted in all 153 patients, with 124 (81%) patients classifiable as mutated or unmutated.