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. 2011 Mar 14;6(3):e14752. doi: 10.1371/journal.pone.0014752

Figure 2. Gene regulatory network for pancreatic cell differentiation.

Figure 2

Master model: Hnf6 activates Pdx1, Ptf1a and Ngn3. Three cross-inhibition gene pairs are Ptf1a-Ngn3, Pax4-Arx and MafA-δ gene. Nodes are denoted by TF names. Arrow-heads denote activation while flat-heads denote inhibition. Circles are variable names in the mathematical model. An alternative model: Pdx1 directly inhibits both Ptf1a and Ngn3.