Figure 7. Noisy gene expression profiles after knocking out Pdx1.

(A) Because all fully differentiated cells have a positive feedback, their marker genes can be activated by noise. Exocrine, α, β and δ cells appear, but their steady state gene expression patterns are different from the normal cells. (B) Noisy gene expression patterns of Exocrine, α, β and δ cells after knocking out Pdx1. White – Initial values; Gray – Maximum value; Black – Final value.