Table 3.
Age- and Multivariable-Adjusted HRs According to Physical Activity Category After Prostate Cancer Diagnosis
| Measure | Total Activity |
P for Trend | ||||
|---|---|---|---|---|---|---|
| < 3 MET-h/wk | 3 to < 9 MET-h/wk | 9 to < 24 MET-h/wk | 24 to < 48 MET-h/wk | ≥ 48 MET-h/wk | ||
| Median MET-hours per week on first postdiagnosis questionnaire | 0.6 | 5.7 | 16 | 33.4 | 71.0 | |
| All deaths (n = 548) | ||||||
| No. of deaths | 125 | 99 | 143 | 116 | 65 | |
| Age-adjusted HR | 1.00 | 0.79 | 0.63 | 0.57 | 0.33 | < .001 |
| 95% CI | 0.60 to 1.04 | 0.49 to 0.80 | 0.44 to 0.73 | 0.24 to 0.45 | ||
| Multivariable-adjusted HR* | 1.00 | 0.81 | 0.70 | 0.66 | 0.40 | < .001 |
| 95% CI | 0.61 to 1.07 | 0.54 to 0.90 | 0.51 to 0.87 | 0.29 to 0.54 | ||
| Multivariable-adjusted HR† | 1.00 | 0.80 | 0.69 | 0.65 | 0.38 | < .001 |
| 95% CI | 0.61 to 1.06 | 0.53 to 0.90 | 0.49 to 0.86 | 0.27 to 0.53 | ||
| Prostate cancer deaths (n = 112) | ||||||
| No. of prostate cancer deaths | 21 | 21 | 25 | 30 | 15 | |
| Age-adjusted HR | 1.00 | 0.90 | 0.61 | 0.85 | 0.41 | .02 |
| 95% CI | 0.49 to 1.67 | 0.34 to 1.10 | 0.48 to 1.50 | 0.21 to 0.80 | ||
| Multivariable-adjusted HR‡ | 1.00 | 0.96 | 0.65 | 0.93 | 0.46 | .04 |
| 95% CI | 0.51 to 1.80 | 0.36 to 1.20 | 0.51 to 1.68 | 0.23 to 0.92 | ||
| Multivariable-adjusted HR§ | 1.00 | 0.91 | 0.60 | 0.83 | 0.42 | .04 |
| 95% CI | 0.48 to 1.73 | 0.32 to 1.11 | 0.44 to 1.55 | 0.20 to 0.88 | ||
NOTE. Physical activity was updated over follow-up. Men were alive for at least 4 years after their postdiagnosis physical activity assessments, and we only used activity information from 4 to 6 years before death.
Abbreviations: HR, hazard ratio; MET, metabolic equivalent task.
Adjusted for age at diagnosis, months since diagnosis, clinical stage, Gleason score, treatment, parental history of myocardial infarction at age 60 years or younger, high blood pressure, elevated cholesterol, and diabetes status from the prediagnostic questionnaire; smoking status, body mass index, and alcohol intake from the first postdiagnostic questionnaire; and comorbidities (coded as yes if participant reported any of the following: myocardial infarction, coronary artery bypass or coronary angioplasty, stroke, Parkinson's disease, and emphysema or chronic bronchitis). This variable was updated over follow-up, and comorbidity status was applied one cycle prior to physical activity exposure.
Additionally adjusted for prediagnosis physical activity.
Adjusted for age at diagnosis, months since diagnosis, clinical stage, Gleason score, treatment, and postdiagnosis body mass index.
Additionally adjusted for prediagnosis physical activity.