Table 4.
Age-and Multivariable-Adjusted HRs According to Duration of Nonvigorous and Vigorous Physical Activity After Prostate Cancer Diagnosis
| Measure | Duration of Nonvigorous Activity |
P for Trend | Duration of Vigorous Activity |
P for Trend | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| < 1 h/wk | 1 to < 3 h/wk | 3 to < 5 h/wk | 5 to < 10 h/wk | ≥ 10 h/wk | < 1 h/wk | 1 to < 3 h/wk | ≥ 3 h/wk | |||
| Median duration per week on first postdiagnosis questionnaire, hours | 0 | 1.6 | 3.5 | 6.0 | 15.5 | 0 | 1.5 | 5 | ||
| All deaths (n = 536) | ||||||||||
| No. of deaths | 178 | 148 | 31 | 126 | 53 | 371 | 122 | 43 | ||
| Age-adjusted HR | 1.00 | 0.78 | 0.63 | 0.66 | 0.44 | < .001 | 1.00 | 0.90 | 0.47 | < .001 |
| 95% CI | 0.62 to 0.98 | 0.43 to 0.94 | 0.52 to 0.84 | 0.32 to 0.61 | 0.73 to 1.11 | 0.34 to 0.65 | ||||
| Multivariable-adjusted HR* | 1.00 | 0.80 | 0.73 | 0.74 | 0.52 | < .001 | 1.00 | 0.98 | 0.50 | < .001 |
| 95% CI | 0.64 to 1.01 | 0.49 to 1.08 | 0.58 to 0.95 | 0.37 to 0.71 | 0.79 to 1.22 | 0.36 to 0.70 | ||||
| Multivariable-adjusted HR† | 1.00 | 0.79 | 0.70 | 0.72 | 0.49 | < .001 | 1.00 | 1.00 | 0.51 | < .001 |
| 95% CI | 0.63 to 1.00 | 0.47 to 1.04 | 0.56 to 0.93 | 0.35 to 0.69 | 0.80 to 1.25 | 0.36 to 0.72 | ||||
| Prostate cancer deaths (n = 111) | ||||||||||
| No. of prostate cancer deaths | 26 | 33 | 11 | 29 | 12 | 71 | 31 | 9 | ||
| Age-adjusted HR | 1.00 | 1.03 | 1.30 | 1.05 | 0.65 | .21 | 1.00 | 1.10 | 0.33 | .04 |
| 95% CI | 0.61 to 1.74 | 0.63 to 2.70 | 0.61 to 1.80 | 0.32 to 1.32 | 0.71 to 1.70 | 0.08 to 1.37 | ||||
| Multivariable-adjusted HR‡ | 1.00 | 1.04 | 1.47 | 1.12 | 0.75 | .41 | 1.00 | 1.17 | 0.46 | .06 |
| 95% CI | 0.61 to 1.78 | 0.69 to 3.12 | 0.64 to 1.97 | 0.37 to 1.52 | 0.74 to 1.83 | 0.23 to 0.94 | ||||
| Multivariable-adjusted HR§ | 1.00 | 1.08 | 1.46 | 1.13 | 0.79 | .46 | 1.00 | 1.13 | 0.39 | .03 |
| 95% CI | 0.63 to 1.87 | 0.68 to 3.14 | 0.64 to 2.01 | 0.37 to 1.66 | 0.70 to 1.83 | 0.18 to 0.84 | ||||
NOTE. Physical activity was updated over follow-up. Men were alive for at least 4 years after their postdiagnosis physical activity assessments, and we only used activity information from 4 to 6 years before death. When examining nonvigorous and vigorous physical activity, we mutually adjusted for both. Twelve men who died (one from prostate cancer) did not contribute to analyses on duration of exercise because they only reported stair climbing as physical activity.
Abbreviation: HR, hazard ratio.
Adjusted for age at diagnosis, months since diagnosis, clinical stage, Gleason score, treatment, parental history of myocardial infarction at age 60 years or younger, high blood pressure, elevated cholesterol, and diabetes status from the prediagnostic questionnaire; smoking status, body mass index, and alcohol intake from the first postdiagnostic questionnaire; and comorbidities (coded as yes if participant reported any of the following: myocardial infarction, coronary artery bypass or coronary angioplasty, stroke, Parkinson's disease, and emphysema or chronic bronchitis). This variable was updated over follow-up, and comorbidity status was applied one cycle prior to physical activity exposure.
Additionally adjusted for prediagnosis physical activity.
Adjusted for age at diagnosis, months since diagnosis, clinical stage, Gleason score, treatment, and postdiagnosis body mass index.
Additionally adjusted for prediagnosis physical activity.